王佳佳，講師

研究方向：肝臟藥理學、腸肝軸及腸道菌群研究

電子郵箱: wjj@ahmu.edu.cn

辦公室：基礎樓405

教育經歷：

(1) 2005/09-2010/07 安徽醫(yī)科大學，藥學院，博士（碩博連讀）

(2) 2000/09-2005/07安徽醫(yī)科大學，藥學院，學士

工作經歷：

(1) 2010/09至今 安徽醫(yī)科大學，藥理教研室，講師

科研項目：

（1）安徽醫(yī)科大學校基礎與臨床合作研究提升計劃項目：基于靶向代謝組學研究腸道菌群雌激素代謝對NASH致肝纖維化的影響及機制(2021xkjT023)

（2）安徽省高校自然科學基金重點項目：植物雌激素毛蕊異黃酮經雌激素受體介導抗肝纖維化作用及其機制（KJ2016A342） 

（3）安徽省高校自然科學基金重點項目：內質網(wǎng)應激在系統(tǒng)性紅斑狼瘡免疫調節(jié)中的作用（KJ2012A149）

發(fā)表論文情況：

1.Yueqin Zhu, Chun Cao, Zihao Li, Zhou Xu, Shishun Qian, Jingrong Zhang, Mengxue Li, Xiaojie Hu, Anqi Zhang, Na Du, Xuesheng Pan, Xinchen Wang, Yancai Sun, Jiajia Wang?, Yan Huang?. ASIC1a regulates ferroptosis in hepatic stellate cells via the Hippo/Yap-1 pathway in liver fibrosis. Int Immunopharmacol. 2024;143(Pt 1):113226.

2.Jiahui Zhou, Xueping Qi, Na Pan, Wanli Li, Haiming Fang?, Jiajia Wang?, Sheng Wang?. A novel UPLC-ESI-MS assay for fifteen portal estrogens and metabolites detection and application in hepatic fibrosis. Anal Biochem, 2023;671:115158. 

3. Haiming Fang?, Tingting Yao, Wanli Li, Na Pan, Hang Xu, Qian Zhao, Yuan Su, Kangwei Xiong, Jiajia Wang?. Efficacy and safety of fecal microbiota transplantation for chronic insomnia in adults: a real world study. Frontiers in Microbiology.2023,14:1299816.

4. Kangwei Xiong, Qian Zhao, Wanli Li, Tingting Yao, Yuan Su, Jiajia Wang?, Haiming Fang?. Comparison of the longterm efficacy and safety of multiple endoscopic rubber band ligations in a single session for varying grades of internal hemorrhoids.  Ir J Med Sci. 2023,192(6):2747-2753.

5. Yaxin Wang, Canyan Wu, Jiahui Zhou, Haiming Fang?, Jiajia Wang?. Overexpression of estrogen receptor β inhibits cellular functions of human hepatic stellate cells and promotes the anti-fibrosis effect of calycosin via inhibiting STAT3 phosphorylation. BMC Pharmacology & Toxicology, 2022;23(1):77. 

6. Mengmeng Zhang, Yaxin Wang, Guannan Zhu, Cheng Sun, Jiajia Wang?. Hepatoprotective effect and possible mechanism of phytoestrogen calycosin on carbon tetrachloride–induced liver fibrosis in mice. Naunyn Schmiedebergs Arch Pharmacol,2021;394(1):189-204. 

7. Jiajia Wang, Guannan Zhu, Cheng Sun, Kangwei Xiong, Tingting Yao, Yuan Su,  Haiming Fang?. TAK-242 ameliorates DSS-induced colitis by regulating the gut microbiota and the JAK2/STAT3 signaling pathway. Microb Cell Fact. 2020;19(1):158.

8.Jing Liu, Tan Deng, Yaxin Wang, Mengmeng Zhang, Guannan Zhu, Haiming Fang?, Jiajia Wang?. Calycosin inhibits intestinal fibrosis on CCD-18Co cells via modulating TGF-β/Smad signaling pathway. Pharmacology. 2019;104:81-89. 

9. Tan Deng, Jing Liu, Mengmeng Zhang, Yaxin Wang, Guannan Zhu, Jiajia Wang?.  Inhibition Effect of Phytoestrogen Calycosin on TGF-β -Induced Hepatic Stellate Cells Activation, Proliferation and Migration via Estrogen Receptor β. Canadian Journal of Physiology and Pharmacology, 2018, 96(12):1268-1275. 

10.Haiming Fang*, Lian Fu, Jiajia Wang*. Protocol for fecal microbiota transplantation in inflammatory bowel disease: a systematic review and meta-analysis. BioMed Research International, 2018;8941340.