張賢政，校聘副教授

研究方向：抗炎免疫藥理學(xué)

電子郵箱：zxzhang@ahmu.edu.cn

辦公室：臨床藥理研究所308室

教育經(jīng)歷：

(1) 2016-09至2021-06,安徽醫(yī)科大學(xué),藥理學(xué),博士（碩博連讀）；

(2) 2012-09至2016-07,皖南醫(yī)學(xué)院,制藥工程,學(xué)士；

工作經(jīng)歷：

(1) 2024-10至今，安徽醫(yī)科大學(xué)藥學(xué)科學(xué)學(xué)院，教師

(2) 2021-08至2024-09,安徽醫(yī)科大學(xué)第一附屬醫(yī)院，博士后；

學(xué)術(shù)兼職：

2023-11，安徽省藥理學(xué)會(huì)抗炎免疫藥理學(xué)專業(yè)委員會(huì)；

2024-04，《抗感染藥學(xué)》青年編委

主持課題項(xiàng)目情況：

(1)國(guó)家自然科學(xué)基金委員會(huì),青年科學(xué)基金項(xiàng)目, 82204403, HIF-1α通過調(diào)控糖酵解途徑促進(jìn)類風(fēng)濕關(guān)節(jié)炎滑膜組織中IL-1β修飾NETs的形成, 2023-01-01至2025-12-31, 30萬元,在研,主持；

(2)中國(guó)博士后基金會(huì),中國(guó)博士后面上項(xiàng)目, 2022M720199,缺氧通過調(diào)控糖酵解途徑促進(jìn)類風(fēng)濕關(guān)節(jié)炎滑膜組織中NETs的形成, 2021-03至2024-08, 8萬元,結(jié)題,主持；

(3)安徽省教育廳,安徽省博士后研究人員科研活動(dòng)資助經(jīng)費(fèi), 2021B509, IgD/IgDR介導(dǎo)B淋巴細(xì)胞活化參與類風(fēng)濕關(guān)節(jié)炎及靶向IgDR單抗的研究, 2021-08至2023-03, 5萬元,結(jié)題,主持；

發(fā)表論文情況：

[1]. Wang H#, Zhao YC#, Xu L#, Zhang TJ#, Liu LH, Zhou MQ, Zhang H, Yang YN, Pan P, Jin L, Zhang ZW,Zhang XZ*, Zhang LL*. HIF-1α mediates mitochondrial damage by down-regulating ALKBH7 expression to promote the aberrant activation of FLS in rheumatoid arthritis. Acta Pharmacol Sin. 2025 Mar 26. doi: 10.1038/s41401-025- 01520-y.(IF=6.9)

[2]. Zhou MQ#, Jin L#, Wan P#, Sun CL#, Fang SQ, Chen Y, Tang YJ, Geng S, Liu LH, Zhang H, Yang YN, Liu QY, He WP, Zhang TJ, Zhao YC, Xu L, Tao L*, Zhao TY*,Zhang XZ*, Zhang LL*. Oleanolic Acid Derivative OA17 Inhibits Trophoblast Apoptosis by Suppressing HIF-1α Nuclear Translocation in SLE-Associated Adverse Pregnancy Outcomes.Phytomedicine,2025,accepted. (IF=6.7)[3]Zhang X#, Zhang Z#, Zhao Y#, Jin L#, Tai Y, Tang Y, Geng S, Zhang H, Zhai Y, Yang Y, Pan P, He P, Fang S, Sun C, Chen Y, Zhou M, Liu L, Wang H, Xu L, Zhang T, Hua J, Wang H, Zhang L.Sodium chloride promotes macrophage pyroptosis and aggravates rheumatoid arthritis by activating SGK1 through GABA receptors Slc6a12[J]. Int J Biol Sci. 2024; 20(8): 2922-2942. Article IF=9.2

[4]Zhao Y#, Wang H#, Jin L, Zhang Z, Liu L, Zhou M,Zhang X*, Zhang L*. Targeting fusion proteins of the interleukin family: A promising new strategy for the treatment of autoinflammatory diseases. Eur J Pharm Sci. 2024 Jan 1;192:106647. (IF=4.6)

[5] Jin L#, Zhang Z#, Pan P#, Zhao Y, Zhou M, Liu L, Zhai Y, Wang H, Xu L, Mei D, Zhang H, Yang Y, Hua J,Zhang X*, Zhang L*. Low-dose ethanol consumption inhibits neutrophil extracellular traps formation to alleviate rheumatoid arthritis. Commun Biol. 2023;6(1):1088.(IF=5.9)

[6] Zhang Z#, Jin L#, Liu L, Zhou M,Zhang X*, Zhang L*. The intricate relationship between autoimmunity disease and neutrophils death patterns: a love-hate story. Apoptosis. 2023;28(9-10):1259-1284. (IF=7.2)

[7] Hong Z#,Zhang X#, Zhang T#, Hu L, Liu R, Wang P, Wang H, Yu Q, Mei D, Xue Z, Zhang F, Zhang L. The ROS/GRK2/HIF-1α/NLRP3 Pathway Mediates Pyroptosis of Fibroblast-Like Synoviocytes and the Regulation of Monomer Derivatives of Paeoniflorin. Oxid Med Cell Longev. 2022;2022:4566851.(IF=7.31)

[8]Zhang X, Mei D, Wang H, Yu Q, Hong Z, Xu L, Ge J, Han L, Shu J, Liang F, Cai X, Zhu Y, Zhang F, Wang Q, Tai Y, Wang H, Zhang L, Wei W. hIgDFc-Ig inhibits B cell function by regulating the BCR-Syk-Btk-NF-κB signalling pathway in mice with collagen-induced arthritis. Pharmacol Res. 2021;173:105873.  Article IF=10.334

[9]Zhang X#, Mei D#, Zhang L, Wei W. Src Family Protein Kinase Controls the Fate of B Cells in Autoimmune Diseases. Inflammation. 2021;44(2):423-433.(IF=4.657)

[10] Han L#,Zhang XZ#, Wang C#, Tang XY, Zhu Y, Cai XY, Wu YJ, Shu JL, Wang QT, Chen JY, Chang Y, Wu HX, Zhang LL, Wei W. IgD-Fc-Ig fusion protein, a new biological agent, inhibits T cell function in CIA rats by inhibiting IgD-IgDR-Lck-NF-κB signaling pathways. Acta Pharmacol Sin. 2020 Jun;41(6):800-812.(IF=6.15)

[11] Shu JL#,Zhang XZ#, Han L#, Zhang F, Wu YJ, Tang XY, Wang C, Tai Y, Wang QT, Chen JY, Chang Y, Wu HX, Zhang LL, Wei W. Paeoniflorin-6'-O-benzene sulfonate alleviates collagen-induced arthritis in mice by downregulating BAFF-TRAF2-NF-κB signaling: comparison with biological agents. Acta Pharmacol Sin. 2019 Jun;40(6):801-813. Article(IF=5.064)