張蕊，校聘副教授

研究方向：乳腺腫瘤干細胞與腫瘤微環(huán)境互作研究

電子郵箱：zhangrui@ahmu.edu.cn

辦公室：藥學科學學院（臨床藥理研究所）311

教育經歷：

(1) 2014-09至2019-06，中國科學技術大學，生物物理，碩博連讀

(2) 2010-09至2014-06，安慶師范大學，生物科學，學士

工作經歷：

(1) 2023-03至今，安徽醫(yī)科大學，臨床藥理研究所，校聘副教授

(2)2019-12至2023-02，復旦大學，附屬腫瘤醫(yī)院 博士后

主持課題項目情況：

（1）國家自然科學基金委員會，青年項目，CCR6通過增強PMN-MDSC富集和免疫抑制能力促進三陰性乳腺癌進展的機制研究（82403663），2025-01-01至2027-12-31，30萬元，在研，主持；
（2）國家自然科學基金委員會，重點項目，乳腺癌生態(tài)系統(tǒng)中調控乳腺癌化療耐藥的關鍵分子及其功能機制研究（82230103），2023-01-01至2027-12-31，261萬元，在研，參與；

（3）安徽省教育廳，重點項目，CCR6+多形核髓源性抑制細胞促進乳腺腫瘤干細胞自我更新的機制研究（2024AH050776），2025-01-01至2027-12-31，10萬元，在研，主持。

發(fā)表論文情況：

(1) Rui Zhang*; Mengxue Dong*; Juchuanli Tu; Fengkai Li; Qiaodan Deng; Jiahui Xu; Xueyan He; Jiajun Ding; Jie Xia; Dandan Sheng; Zhaoxia Chang; Wei Ma; Haonan Dong; Yi Zhang; Lixing Zhang; Lu Zhang; Suling Liu ; PMN-MDSCs modulated by CCL20 from cancer cells promoted breast cancer cell stemness through CXCL2-CXCR2 pathway, Signal Transduction and Targeted Therapy, 2023, 8(1): 97 98 (IF：40.80)

(2) Rui Zhang*; Juchuanli Tu*; Suling Liu ; Novel molecular regulators of breast cancer stem cell plasticity and heterogeneity, Seminars in Cancer Biology, 2021, 205(5) (IF：15.707)

(3)Rui Zhang; Jun Wang; HuR stabilizes TFAM mRNA in an ATM/p38-dependent manner in ionizing irradiated cancer cells, Cancer Science, 2018, 109(8): 2446-2457. (IF：6.716)

(4) Caiqi Xu; Yaoyao Wu; Sui Yang; Xuechun Zhao; Hao Zhang; Xuechun Zhao; Jiemin Zhao; Wei Wei; Qian Meng; Yujuan Wang;Rui Zhang,Inhibition of DJ-1 induces TFAM secretion from cancer cells to suppress tumor growth via promoting M1 macrophage polarization,Cellular Signalling,2025,131:111765. (通訊作者，IF:4.4)

(5) Dandan Sheng*; Wei Ma*; Rui Zhang*; Lei Zhou; Qiaodan Deng; Juchuanli Tu; Wankun Chen; Fuchuang Zhang; Nailong Gao; Mengxue Dong; Dong Wang; Fengkai Li; Yin Liu; Xueyan He; Shengzhong Duan; Lixing Zhang; Tong Liu; Suling Liu ; Ccl3 enhances docetaxel chemosensitivity in breast cancer by triggering proinflammatory macrophage polarization, Journal for ImmunoTherapy of Cancer, 2022, 10(5): e003793-e003793.(共同第一作者，IF：12.469)

(6) Fan Tang*; Rui Zhang*; Jun Wang ; Cyclooxygenase-2-Mediated Up-Regulation of Mitochondrial Transcription Factor A Mitigates the Radio-Sensitivity of Cancer Cells, International Journal of Molecular Sciences, 2019, 20(5): 0-1218.(共同第一作者，IF：5.924)

(7) Qian Meng*, Meng-hui Guo*, Rui Zhang*, Jing Wei, Qian Chen, Xue-chun Zhao, Cai-qi Xu, Yao-yao Wu, Jia-jie Kuai,Jie-min Zhao, Yu-jing Wu, Chong-huan Ye, Hong-rui Wei, Xia Zhu, Yan Jin, Zhi Zhang, and Wei Wei; G-protein coupled receptor kinase 2 mediates rheumatoid arthritis-induced depression-like behaviors via the hippocampal CRHR1 signaling pathway,Acta Pharmacologica Sinica; 2025;0:1–13. (共同第一作者，IF：8.20)

(8) Jiahui Xu, Xiaoli Yang, Qiaodan Deng, Cong Yang, Dong Wang, Guojuan Jiang, Xiaohong Yao, Xueyan He,Jiajun Ding, Jiankun Qiang, Juchuanli Tu, Rui zhang, Qun-Ying Lei, Zhi-min Shao, Xiuwu Bian,Ronggui Hu, Lixing Zhang & Suling Liu; TEM8 marks neovasculogenic tumor-initiating cellsin triple-negative breast cancer, Nature Communications; 2021; 12:4413. (IF：15.7)

(9) Jie Xia, Lixing Zhang, Xilei Peng, Juchuanli Tu, Siqin Li, Xueyan He, Fengkai Li, Jiankun Qiang,Haonan Dong, Qiaodan Deng, Cuicui Liu, Jiahui Xu, Rui Zhang, Quentin Liu, Guohong Hu,Chong Liu, Yi-Zhou Jiang, Zhi-Ming Shao, Ceshi Chen and Suling Liu; IL1R2 Blockade Alleviates Immunosuppression andPotentiates Anti-PD-1 Efficacy in Triple-Negative BreastCancer;Cancer Research, 2024;84:2282-96. (IF：13.4)