楊雪枝，副教授

  醫(yī)學(xué)博士，博士后，副教授，碩士生導(dǎo)師。2021年安徽醫(yī)科大學(xué)引進(jìn)人才。安徽省藥理學(xué)會(huì)抗炎免疫藥理學(xué)專委會(huì)副秘書長。中國藥理學(xué)會(huì)抗炎免疫藥理專委會(huì)青年委員。中國藥理學(xué)會(huì)網(wǎng)絡(luò)藥理學(xué)專委會(huì)青年委員。獲2021年安徽醫(yī)科大學(xué)復(fù)元科技新星。指導(dǎo)學(xué)生獲第十屆安徽省“挑戰(zhàn)杯”比賽銀獎(jiǎng)。

研究方向：抗炎免疫藥理學(xué)

電子郵箱：yangxuezhi@ahmu.edu.cn

科研項(xiàng)目：

（1）國家自然科學(xué)基金面上項(xiàng)目，82473931，2025-01-01至2028-12-31，在研，主持

（2）安徽省科學(xué)技術(shù)協(xié)會(huì)青年科技人才托舉計(jì)劃項(xiàng)目，RCTJ202427，2025-01-01至2027-12-31，在研，主持

（3）安徽省自然科學(xué)基金面上項(xiàng)目，2408085MH218，2024-09至2027-09，在研，主持（4）安徽省轉(zhuǎn)化醫(yī)學(xué)研究院重點(diǎn)項(xiàng)目，2022zhyx-B04，2023-01至2025-12，在研，主持

（5）安徽醫(yī)科大學(xué)第三附屬醫(yī)院基礎(chǔ)與臨床合作研究提升計(jì)劃培育專項(xiàng)（一般項(xiàng)目），2022sfy015，2023-01至2025-12，在研，主持

（6）國家自然科學(xué)青年科學(xué)基金項(xiàng)目，82003763，2021-01-01至2023-12-31，結(jié)題，主持

代表性論文：

1.Yang X, Zhao Y, Wei Q, Zhu X, Wang L, Zhang W, Liu X, Kuai J, Wang F, Wei W. GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis. Acta Pharm Sin B. 2024;14(1):241-255.

2.Yang X,Zhang W, Wang L, Zhao Y, Wei W. Metabolite-sensing GPCRs in rheumatoid arthritis. Trends Pharmacol Sci. 2024;45(2):118-133.

3. Wei Q, Zhu X, Wang L, Zhang W,Yang X, Wei W. Extracellular matrix in synovium development, homeostasis and arthritis disease. Int Immunopharmacol. 2023; 121:110453.

4.Zhao Y,Yang X, Li S, Zhang B, Li S, Wang X, Wang Y, Jia C, Chang Y, Wei W. sTNFRII-Fc modification protects human UC-MSCs against apoptosis/autophagy induced by TNF-α and enhances their efficacy in alleviating inflammatory arthritis. Stem Cell Res Ther. 2021;12(1):535.5.Yang X, Wei W. CP-25, a compound derived from paeoniflorin: research advance on its pharmacological actions and mechanisms in the treatment of inflammation and immune diseases. Acta Pharmacol Sin. 2020;41(11):1387-1394.6.Yang X, Chang Y, Wei W. Emerging role of targeting macrophages in rheumatoid arthritis: Focus on polarization, metabolism and apoptosis. Cell Prolif. 2020;53(7): e12854.

7.Yang X, Li S, Zhao Y, Li S, Zhao T, Tai Y, Zhang B, Wang X, Wang C, Chen J, Wang Q, Zhang L, Xu D, Chang Y, Wei W. GRK2 Mediated Abnormal Transduction of PGE2-EP4-cAMP-CREB Signaling Induces the Imbalance of Macrophages Polarization in Collagen-Induced Arthritis Mice. Cells-basel. 2019;8(12):1596.

8.Yang X, Zhao Y, Jia X, Wang C, Wu Y, Zhang L, Chang Y, Wei W. CP-25 combined with MTX/ LEF ameliorates the progression of adjuvant-induced arthritis by the inhibition on GRK2 translocation. Biomed Pharmacother. 2019;110:834-843.