張世浩，校聘教授

研究方向：組織穩(wěn)態(tài)與腫瘤發(fā)生

電子郵箱：shihaozhang@ahmu.edu.cn

辦公室：臨床藥理研究所309

教育經(jīng)歷：

(1) 2011/09-2017/06，廈門大學(xué)，生命科學(xué)學(xué)院，博士（碩博連讀）

(2) 2007/09-2011/06，泰山醫(yī)學(xué)院，生命科學(xué)學(xué)院，學(xué)士

工作經(jīng)歷：

(1) 2020/09至今，安徽醫(yī)科大學(xué)，藥學(xué)科學(xué)學(xué)院，校聘教授

(2) 2017/07-2020/08，廈門大學(xué)，生命科學(xué)學(xué)院，博士后

學(xué)術(shù)榮譽(yù)：

2020/07，中國(guó)博士后創(chuàng)新人才支持計(jì)劃

科研項(xiàng)目：

（1） 國(guó)家自然科學(xué)基金委員會(huì),面上項(xiàng)目, 82273043, YAP乳酸化修飾在肝細(xì)胞癌發(fā)生中的作用機(jī)制研究,2023-01-01至2026-12-31, 52萬(wàn)元,在研,主持

（2）國(guó)家自然科學(xué)基金委員會(huì),面上項(xiàng)目,81871973，Hippo信號(hào)通路維持膽汁酸代謝平衡及其紊亂導(dǎo)致肝癌產(chǎn)生的功能與機(jī)制研究，2019-01-01至2022-12-31，57萬(wàn)元,結(jié)題,主持

（3）安徽省教育廳，安徽省教育廳優(yōu)秀青年項(xiàng)目, 2022AH030081,肝再生與肝癌發(fā)生, 2022-12至2025-12, 50萬(wàn)元,在研,主持

發(fā)表論文情況：

1.Ji Jiang, Pengfei Ye, Ningning Sun, Weihua Zhu, Mei Yang, Manman Yu, Jingjing Yu, Hui Zhang, Zijie Gao, Ningjie Zhang, Shijie Guo, Yuru Ji, Siqi Li, Cuncun Zhang, Sainan Miao, Mengqi Chai, Wenmin Liu, Yue An, Jian Hong, Wei Wei*,Shihao Zhang*, Huan Qiu*.Yap methylation-induced FGL1 expression suppresses anti-tumor immunity and promotes tumor progression in KRAS-driven lung adenocarcinoma.Cancer communications, 28 September 2024.（IF：20.10）

2.Jiajie Tu, Weile Chen, Wei Huang, Xinming Wang, Yilong Fang, Xuming Wu, Huiru Zhang, Chong Liu, Xuewen Tan, Xiangling Zhu, Huihui Wang, Dafei Han, Yizhao Chen, Anqi Wang, Yuanyuan Zhou, Zimeng Xue, Hui Xue, Shangxue Yan, Lingling Zhang, Zhenbao Li, Chunlan Yang, Yujie Deng,Shihao Zhang*, Chen Zhu*, Wei Wei*.Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development.Annals of the Rheumatic Diseases,November 14, 2024.（IF：20.30）

3.Paipai Guo; Ji Jiang; Rui Chu; Feng He; Mingli Ge; Ruhong Fang; Qiuyun Guan; Huijuan Cheng; Chunru Jiang; Tiantian Su; Zhenduo Zhu; Hao Liu; Wei Wei*; Shihao Zhang* ; Qingtong Wang* ; GRK2 mediated degradation of SAV1 initiates hyperplasia of fibroblast-like synoviocytes in rheumatoid arthritis,Acta Pharmaceutica Sinica B, 2023. (IF:14.70)

4.Chang-yong Xu, Ji Jiang, Yue An, Peng-fei Ye, Cun-cun Zhang, Ning-ning Sun, Sai-nan Miao, Meng-qi Chai, Wen-min Liu, Mei Yang, Wei-hua Zhu, Jing-jing Yu, Man-man Yu, Wu-yi Sun, Huan Qiu*,Shi-hao Zhang*,Wei Wei*.Angiotensin II type-2 receptor signaling facilitates liver injury repair and regeneration via inactivation of Hippo pathway.Acta Pharmacologica Sinica. 45, pages 1201–1213 2024.（IF：6.90）

5.Cuncun Zhang, Ningning Sun, Qingze Fei, Linlin Peng, Chengyu Wei, Xiangyu Liu, Sainan Miao, Mengqi Chai, Fang Wang, Di Wang, Jingfang Hong, Shenghai Huang,Shihao Zhang*, Huan Qiu*. MEN1 deficiency stabilizes PD-L1 and promotes tumor immune evasion of lung cancer.Cancer Science, 30 April 2024.（IF：4.50）

7.Yue An; Changyong Xu; Wenmin Liu; Ji Jiang; Pengfei Ye; Mei Yang; Weihua Zhu; Jingjing Yu; Manman Yu; Wuyi Sun; Jian Hong; Huan Qiu*; Wei Wei*;Shihao Zhang*; Angiotensin II type-2 receptor attenuates liver fibrosis progression by suppressing IRE1α-XBP1 pathway,Cellular Signalling, 2024, 113: 110935（IF：4.80）