邵君棠，博士，副教授，碩士生導(dǎo)師

  博士，副教授，碩士生導(dǎo)師，獲評省海外高層次人才。美國南加州大學(xué)醫(yī)藥科學(xué)博士，曾在全球知名藥企美國勃林格殷格翰制藥公司任高級研究員，從事創(chuàng)新藥物研發(fā)和管理。2019年加入安徽醫(yī)科大學(xué)藥理學(xué)教研室，研究方向為肝臟疾病的病理機制及藥物作用新靶點的發(fā)現(xiàn)、新型藥物靶向遞呈系統(tǒng)的研發(fā)，主持國家自然科學(xué)青年基金項目、省留學(xué)人員創(chuàng)新項目擇優(yōu)資助計劃、省高校自然科學(xué)重點項目各1項，省轉(zhuǎn)化研究院重點項目1項，校級科研基金3項，參與國家自然科學(xué)聯(lián)合基金項目1項，發(fā)表SCI論文多篇。任中國藥理學(xué)會抗炎免疫藥理專業(yè)委員會首屆青委會委員。

研究方向：1.肝臟疾病的病理機制及藥物作用新靶點的發(fā)現(xiàn)

      2.生物藥物PK/PD，藥物靶向遞呈系統(tǒng)（DDS）

電子郵箱：juntangshao@outlook.com

教育經(jīng)歷：

1.2007年-2011年 中國藥科大學(xué)國家理科基地班理學(xué)學(xué)士

2.2011年-2016年 美國南加州大學(xué)醫(yī)藥科學(xué)博士

工作經(jīng)歷：
1.2016年-2019年 美國勃林格殷格翰制藥公司藥物代謝和動力學(xué)部門高級研究員

2.2019年至2020年 安徽醫(yī)科大學(xué)藥理學(xué)教研室校聘副教授

3.2020年至今 安徽醫(yī)科大學(xué)藥理學(xué)教研室副教授

學(xué)術(shù)榮譽：

入選安徽省海外高層次人才引進計劃

科研項目：

（1）安徽省留學(xué)人員創(chuàng)新項目擇優(yōu)資助計劃項目，新型神經(jīng)因子MANF改善酒精誘導(dǎo)的肝脂肪變性及機制，2020LCX020，5萬元,主持。

（2）安徽省高校自然科學(xué)研究重點項目，肝細胞源性神經(jīng)營養(yǎng)因子MANF通過調(diào)控精氨基琥珀酸合酶改善酒精誘導(dǎo)的肝脂肪變性，KJ2020A0137，6萬元,主持。

（3）國家自然科學(xué)基金委員會青年項目, 882100629,神經(jīng)因子MANF通過增強精氨基琥珀酸合酶活性發(fā)揮拮抗酒精性肝臟脂肪變性的作用，2022-2024，30萬元，主持。

（4）安徽醫(yī)科大學(xué)科研水平提升計劃，2022xkjT002,肝細胞SAMHD1通過核轉(zhuǎn)移抑制HCC進展和機制，2023-2025，30萬元，主持。

（5）安徽省轉(zhuǎn)化醫(yī)學(xué)研究院科研基金項目,過氧化物酶6特異性酶檢測方法的研發(fā)及在肝臟原發(fā)惡性腫瘤診斷中的應(yīng)用,2024-2026，20萬元，主持。

發(fā)表論文情況：

1)Juntang Shao#*, Wei Wang#, Shiyu Li, Guangfa Yin, Lili Han, Xinyu Wang, Meng Cai, Tao Yang, Ying Wang, Wenyan Qu, Yanhong Jiao, Peng Wang, Hanyang Xu, Xu Zhu, Songcheng Ying, Sa Xu, Qiang Sheng, Jian Fang, Tongcui Jiang, Chuansheng Wei, Yujun Shen, Yuxian Shen*. Nuclear Overexpression of SAMHD1 Induces M Phase Stalling in Hepatoma Cells and Suppresses HCC Progression by Interacting with the Cohesin Complex. Advanced Science. 2024 Dec 16:e2411988. doi: 10.1002/advs.202411988.

2)Han-Yang Xu, Yan-Hong Jiao, Shi-Yu Li, Xu Zhu, Sheng Wang, Yu-Yang Zhang, Yi-Jun Wei, Yu-Jun Shen, Wei Wang, Yu-Xian Shen*, Jun-Tang Shao*, Hepatocyte-derived MANF mitigates ethanol-induced liver steatosis in mice via enhancing ASS1 activity and activating AMPK pathway. Acta Pharmacologica Sinica. 2022: 1-12. doi: 10.1038/s41401-022-00920-8.

3)Xin-xin Ling, Hua Chen, Bei-bei Fu, Cheng-shao Ruan, Ming Pana, Kai Zhou, Zhi-rui Fang, Jun-tang Shao*, Feng-qin Zhu*, Shan Gao*, Xin-Ji-Er-Kang protects myocardial and renal injury in hypertensive heart failure in mice, Phytomedicine, 91, p.153675. doi: 10.1016/j.phymed.2021.153675.

4)Juntang Shao*, Jennica Zaro, Yuxian Shen*; Advances in Exosome-Based Drug Delivery and Tumor Targeting: From Tissue Distribution to Intracellular Fate, International Journal of Nanomedicine, 2020, 15: 9355-9371. doi: 10.2147/IJN.S281890.

5)Can Liu, Jun Liu, Juntang Shao, Cheng Huang, Xingliang Dai, Yujun Shen, Weishu Hou, Yuxian Shen, Yongqiang Yu; MAGED4B Promotes Glioma Progression via Inactivation of the TNF-α-induced Apoptotic Pathway by Down-regulating TRIM27 Expression. Neurosci Bull. 2022 Aug 20. doi: 10.1007/s12264-022-00926-6.

6)Goma Chhetri, Yanyan Liang, Juntang Shao, Dan Han, Yi Yang, Chao Hou, Peng Wang, XiaoFang Tao, Yujun Shen, Tongcui Jiang, Lijie Feng, Yuxian Shen*, Role of Mesencephalic Astrocyte-Derived Neurotrophic Factor in Alcohol-Induced Liver Injury, Oxidative Medicine and Cellular Longevity, 2020: 0-9034864.

7)Yuqian Liu#, Hsuan-Yao Wang#, Juntang Shao, Jennica Zaro, Wei-Chiang Shen*; Enhanced insulin receptor interaction by a bifunctional insulin-transferrin fusion protein: an approach to overcome insulin resistance, Scientific reports vol. 10,1 7724. 7 May. 2020, doi:10.1038/s41598-020-64731-9

8)Chao Hou?, Dong Wang?, Mingxia Zhao?, Petek Ballar, Xinru Zhang, Qiong Mei, Wei Wang, Xiang Li, Qiang Sheng, Jun Liu, Chuansheng Wei, Yujun Shen, Yi Yang, Peng Wang, Juntang Shao, Sa Xu, Fuyan Wang, Yang Sun*, Yuxian Shen* (2023). MANF brakes TLR4 signaling by competitively binding S100A8 with S100A9 to regulate macrophage phenotypes in hepatic fibrosis. Acta pharmaceutica Sinica. B, 13(10), 4234–4252.

9)Wang, Ting, Andrea Whitcher-Johnstone, Young_Sun Scaringella, Monica Keith-Luzzi, Juntang Shao, Mitchell E. Taub, and Tom S. Chan. Comparison of Commonly Used and New Methods to Determine Small Molecule Non-Specific Binding to Human Liver Microsomes. Journal of Pharmaceutical Sciences 113, no. 7 (2024): 1987-1995

10) Yanyan Liang, Qiong Mei, Enguang He, Petek Ballar, Chuansheng Wei, Yue Wang, Yue Dong, Jie Zhou, Xiaofang Tao, Wenyan Qu, Mingxia Zhao, Goma Chhetri, Limeng Wei, Juntang Shao, Yujun Shen, Jun Liu, Lijie Feng, Yuxian Shen MANF serves as a novel hepatocyte factor to promote liver regeneration after 2/3 partial hepatectomy via doubly targeting Wnt/β-catenin signaling. Cell Death & Disease 15, no. 9 (2024): 681.

11)Juntang Shao, Jennica L. Zaro, Wei-Chiang Shen*; Proinsulin–Transferrin Fusion Protein Exhibits a Prolonged and Selective Effect on the Control of Hepatic Glucose Production in an Experimental Model of TypeDiabetes., Molecular Pharmaceutics, 2016, 13(8): 2641-2646.

12)Yan Wang, Juntang Shao, Jennica L. Zaro, Wei-Chiang Shen*; Proinsulin-transferrin fusion protein as a novel long-acting insulin analog for the inhibition of hepatic glucose production. Diabetes, 2014, 63(5): 1779-1788.