文繼月，博士，副教授，碩士生導師

研究方向：神經(jīng)藥理學

電子郵箱：wenjiyue139@aliyun.com

主持課題項目情況：

1.H₂S調(diào)控RhoA-ROCK/PKA/BK_Ca信號通路介導星形膠質(zhì)細胞活化為抗炎表型，安徽省高校自然科學研究項目，主持，在研。

2. H₂S促進A2型星形膠質(zhì)細胞活化在映山紅花總黃酮抗缺血性腦中風中的作用及機制研究，安徽省自然科學基金，主持，在研。

3.神經(jīng)源性H₂S抑制RhoA/ROCK2通路在腦缺血后星形膠質(zhì)細胞表型轉(zhuǎn)換中的作用及機制研究，安徽省高校自然科學研究項目，主持，已結(jié)題。

4.戊型肝炎病毒基因特異性中和抗原表位與免疫逃逸的研究，安徽醫(yī)科大學博士科研資助項目，主持，已結(jié)題。

5.基于循環(huán)血液外泌體RNA的前列腺癌早期診斷標志物的篩選與鑒定及相關試劑盒的研發(fā)，安徽省轉(zhuǎn)化醫(yī)學研究院科研基金項目，合作主持，已結(jié)題。

發(fā)表論文情況：

1. Zhifeng Geng, Guoyi Deng, Ziyu Wang, Xin Xu, Xiaojiao Yin, Sen Zhang, Jiale Shao, Jiyue Wen*. Distinct roles of A1/A2 astrocytes in blood-brain barrier injury following cerebral I/R via the ROCK/NF-κB and STAT3 pathways. International Immunopharmacology. 2025, 151:114338.

2. Weizhuo Lu and Jiyue Wen*. Metabolic reprogramming and astrocytes polarization following ischemic stroke. Free Radical Biology and Medicine. 2025, 228:197-206.

3. Weizhuo Lu and Jiyue Wen*. The relationship among H2S, neuroinflammation and MMP-9 in BBB injury following ischemic stroke. International Immunopharmacology. 2025, 146:113902.

4. Weizhuo Lu and Jiyue Wen*. Anti-inflammatory effects of hydrogen sulfide in axes between gut and other organs. Antioxidants & Redox Signaling. 2024 Dec 10, Online ahead of print.

5. Weizhuo Lu and Jiyue Wen*. Neuroinflammation and post-stroke depression: focus on the microglia and astrocytes. Aging and Disease. 2024, 16(1):394-407.

6. Weizhuo Lu and Jiyue Wen*. The roles of RhoA/ROCK/NF-κB pathway in microglia polarization following ischemic stroke. Journal of Neuroimmune Pharmacology. 2024, 16;19(1):19.

7. Jiyue Wen, Jie Zhang, Shuo Chen, Ye Chen, Yang Zhang, Ziyao Ma, Fang Zhang, Weiming Xie, Yifei Fan*, Jingsi Duan*, Zhiwu Chen*. Endothelium-derived hydrogen sulfide acts as a hyperpolarizing factor and exerts neuroprotective effects via activation of large-conductance Ca²⁺-activated K⁺ channels. British Journal of Pharmacology. 2021, 178(20):4155-4175.

8.Xiaojiao Yin, Bo Liu, Yanyu Ding, Xueyan Li, Ju Sheng, Yan Guo, Zhiwu Chen*, Jiyue Wen*. Total flavones of Rhododendron induce the transformation of A1/A2 astrocytes via promoting the release of CBS-produced H₂S. Phytomedicine. 2023,111:154666.

9.Yanyu Ding, Fang Fang, Xiaolong Liu, Shuyan Sheng, Xueyan Li, Xiaojiao Yin, Zhiwu Chen*, Jiyue Wen*. H₂S regulates the phenotypic transformation of astrocytes following cerebral ischemia/reperfusion via inhibiting the RhoA/ROCK pathway. Molecular Neurobiology. 2024, 61(6):3179-3197.

10.Weizhuo Lu, Zhiwu Chen* and Jiyue Wen*. The role of RhoA/ROCK pathway in the ischemic stroke-induced neuroinflammation. Biomedicine & Pharmacotherapy. 2023, 165:115141.

11. Xueyan Li, Xiaojiao Yin, Jiazhuang Pang, Zhiwu Chen* and Jiyue Wen*. Hydrogen sulfide inhibits lipopolysaccharide-based neuroinflammation-induced astrocyte polarization after cerebral ischemia/reperfusion injury. European Journal Pharmacology. 2023, 949:175743.

12. Weizhuo Lu and Jiyue Wen*. Crosstalk among glial cells in the blood-brain barrier injury after ischemic stroke. Molecular Neurobiology. 2024, 61(9):6161-6174. IF:4.6

13. Weizhuo Lu and Jiyue Wen*. H₂S-RhoA/ROCK pathway and glial cells in axonal remyelination after ischemic stroke. Molecular Neurobiology.2023, 60(9):5493-5504.

14. Yanyu Ding, Bo Liu, Yang Zhang, Fang Fang, Xueyan Li, Song Wang*, Jiyue Wen*. Hydrogen sulphide protects mice against the mutual aggravation of cerebral ischaemia/reperfusion injury and colitis. European Journal of Pharmacology. 2022, 914:174682.

15.Yang Zhang, Kexin Li, Xiangyi Wang, Yanyu Ding, Ziruo Ren, Jinglong Fang, Tao Sun, Yan Guo*, Zhiwu Chen*, Jiyue Wen*. CSE-Derived H₂S inhibits reactive astrocytes proliferation and promotes neural functional recovery after cerebral ischemia/reperfusion injury in mice via inhibition of RhoA/ROCK2 pathway. ACS Chemical Neuroscience. 2021,12(14):2580-2590.

16.Ye Chen, Jiyue Wen*, Zhiwu Chen*. H₂S protects hippocampal neurons against hypoxia-reoxygenation injury by promoting RhoA phosphorylation at Ser188. Cell Death and Discovery. 2021, 7(1):132.

17.Weizhuo Lu, Jiyue Wen*. H₂S-mediated inhibition of RhoA/ROCK pathway and noncoding RNAs in ischemic stroke. Metabolic Brain Disease. 2023, 38(1):163-176.

18.Weizhuo Lu, Zhiwu Chen*, Jiyue Wen*. RhoA/ROCK signaling pathway and astrocytes in ischemic stroke. Metabolic Brain Disease. 2021, 36(6):1101-1108.

19. Jinhua Chen, Xiaohong Ding, Wei Chen, Shuo Chen, Qianjun Guan, Jiyue Wen*, Zhiwu Chen*. VEGFR2 in vascular smooth muscle cells mediates H2S-induced dilation of the rat cerebral basilar artery. Microvascular Research. 2022, 141:104309.

20.Fang Zhang, Shuo Chen, Jiyue Wen*, Zhiwu Chen*. 3-Mercaptopyruvate sulfurtransferase/hydrogen sulfide protects cerebral endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury via mitoprotection and inhibition of the RhoA/ROCK pathway. American Journal Physiology Cell Physiology. 2020, 319(4):C720-C733.

21.Yan Guo, Xiaomeng Yu, Shuo Chen, Jiyue Wen*, Zhiwu Chen*. Total flavones of Rhododendron simsii Planch flower protect rat hippocampal neuron from hypoxia-reoxygenation injury via activation of BK channel. Journal of Pharmacy and Pharmacology. 2020,72(1):111-120.

22.Jiyue Wen, Shanshan Gao, Fanglin Chen, Shuo Chen, Mei Wang, Zhiwu Chen*. Role of CSE-Produced H2S on cerebrovascular relaxation via RhoA-ROCK inhibition and cerebral ischemia-reperfusion injury in mice. ACS Chemical Neuroscience. 2019, 20;10(3):1565-1574.

23.Jiyue Wen, Mei Wang, Yanan Li, Huihui Jiang, Xuanjun Sun, Zhiwu Chen*.Vascular protection of Hydrogen Sulfide on cerebral ischemia/reperfusion injury in rats. Frontiers in neurology. 2018, 9: 779.