張貴陽(yáng)，博士，副教授

  2018年畢業(yè)于南京大學(xué)，獲博士學(xué)位。

  長(zhǎng)期從事藥物靶向遞送組裝體系研究。主持安徽省面上項(xiàng)目、安徽省教育廳項(xiàng)目、安徽省轉(zhuǎn)化醫(yī)學(xué)研究院培育項(xiàng)目及安徽醫(yī)科大學(xué)基礎(chǔ)與臨床合作研究項(xiàng)目各1項(xiàng)；發(fā)表科研文章30余篇，其中SCI收錄30篇。以第一作者或通訊作者身份在Nature Communications、Small、Chemical Engineering Journal、Advanced Healthcare Materials、ACS Applied Materials & Interfaces等期刊發(fā)表多篇研究成果；以最后通訊作者身份受邀發(fā)表兩篇關(guān)于COF在遞送小分子或大分子藥物中的綜述。獨(dú)立撰寫(xiě)英文著作章節(jié)Covalent Organic Frameworks（ISBN 978-1-80356-960-4；DOI: 10.5772/intechopen.102264）；獲授權(quán)國(guó)家專(zhuān)利三項(xiàng)；2023年入選Asian Journal of Pharmaceutical Sciences、Exploration、iMeta和Biomaterials Translational青年編委。至今已指導(dǎo)畢業(yè)碩士研究生6名，其中全部榮獲“國(guó)家獎(jiǎng)學(xué)金”。

郵箱：guiyangzhang@ahmu.edu.cn

工作經(jīng)歷：

1.2020.9 -至今  安徽醫(yī)科大學(xué)，基礎(chǔ)醫(yī)學(xué)院，工作，副教授

2.2015.10-2020.09  南京大學(xué)，高分子化學(xué)與物理，導(dǎo)師：賈敘東，襲鍇教授

主持或參加科研項(xiàng)目：

(1)安徽省轉(zhuǎn)化醫(yī)學(xué)研究院,培育項(xiàng)目, 2022zhyx-C13,主動(dòng)透皮釋藥COFs貼片技術(shù)開(kāi)

發(fā), 2023-01至2025-12, 8萬(wàn)元,在研,主持

(2)安徽醫(yī)科大學(xué),安徽醫(yī)科大學(xué)基礎(chǔ)與臨床合作研究項(xiàng)目, 2021xkjT024,基于COFs的

納米藥物載體設(shè)計(jì)及其用于腎癌腦轉(zhuǎn)移治療的研究, 2022-01至2024-12, 20萬(wàn)元,在研,

主持

(3)安徽省高等學(xué)校自然科學(xué)研究項(xiàng)目,重點(diǎn)項(xiàng)目, KJ2019A0942,基于刺激-觸發(fā)開(kāi)關(guān)誘

導(dǎo)聚集的苯硼酸脂生物響應(yīng)材料的設(shè)計(jì)、制備與性能研究, 2019-07至2021-07, 6萬(wàn)元,

結(jié)題,主持

(4)安徽省自然科學(xué)基金項(xiàng)目，面上項(xiàng)目，2408085MH196，糖基化蛋白捕獲與活性氧清除COF體系的構(gòu)建及其調(diào)控巨噬細(xì)胞抗糖尿病心肌病的研究，2024-09-01至2027-08-31，8萬(wàn)元，在研，主持

研究方向:藥物靶向遞送

代表性論文與專(zhuān)著（通訊作者*）：

[1]Guiyang Zhang, Xinle Li, Qiaobo Liao, Yanfeng Liu, Kai Xi*, Wenyu Huang* Xudong Jia*. Water-dispersible PEG-curcumin/amine-functionalized covalent organic framework nanocomposites as smart carriers for in vivo drug delivery.Nature Communications,2018, 9, 2785.  (IF: 14.7)

[2] Jin Wu, Tao Meng, Xiaoqian Zhang, Songtao Tang, Lei Liu, Jing Xue, Xiaohui Liu, Junjun Wang, Jiyue Wen*, Danyou Hu*,Guiyang Zhang*. Glucose‐Responsive Zn(II)‐Porphyrin COF Adhesive Hydrogels With Dual‐Active Sites and GOX‐Like Activity for Accelerated Wound Healing. Advanced Healthcare Materials,2025, 2404076.  (IF: 10)

[3]Chen Wang, Junyan He, Zhongyao Hu, Yiqun Yan, Zelin Xu, Yangmang Yu, Jingwen Su, Bing Ma, Haoran Yu*,Guiyang Zhang*, Wendan Cheng*. An injectable reactive oxygen species-responsive self-assembled hydrogel loaded with L-glutamine targets cartilage repair for treatment of osteoarthritis. Chemical Engineering Journal,2025, 505, 159529.  (IF: 13.4)

[4] Saisai Ge, Xinyue Wang, Xinru Zhao, Lingling Yuan, Xuewei Bao, Caidie Sun, Zehua Gong, Jun Guo, Siyu Yuan, Danyou Hu, Jing Yang*, Bin Yuan*,Guiyang Zhang*. Responsive Multi-Arm PEG-Modified COF Nanocomposites: Dynamic Photothermal, pH/ROS Dual-Responsive, Targeted Carriers for Rheumatoid Arthritis Treatment, Advanced Healthcare Materials,2024, 2401744.  (IF: 10)

 [5] Jialu Zhuang, Hao Zhang, Jin Wu, Danyou Hu, Tao Meng, Jing Xue, Hanyang Xu, Gang Wang*, Hua Wang*,Guiyang Zhang*. Redox-Responsive AIEgen Diselenide-Covalent Organic Framework Composites Targeting Hepatic Macrophages for Treatment of Drug-induced Liver Injury. Small.2024. 2402656.  (IF: 13)

[6] Jing Xue, Jialu Zhuang, Xinyue Wang, Tao Meng, Jin Wu, Xiaoqian Zhang, andGuiyang Zhang*. Mechanisms and Therapeutic Strategies for Myocardial Ischemia-Reperfusion Injury in Diabetic States. ACS Pharmacology & Translational Science.2024, DOI: 10.1021/acsptsci.4c00272.  (IF: 5.1)

[7] Neng Jin, Jin Wu, Shuming Ye*, Jing Xue, Tao Meng, Liang Hu, Shangshang Jiang, Hanyang Xu, Yue Yu*, Danyou Hu*,Guiyang Zhang*. Injectable Dynamic ROS-Responsive COF-Modified Microalgae Gels for In Vivo bFGF Delivery to Treat Diabetic Wounds. ACS Applied Materials & Interfaces,2024, 16, 15, 18608–18626.  (IF: 8.5)

[8] Tao Meng, Xinyue Wang, Shangshang Jiang, Si-rui Chen, Shengnan Zhou, Yuheng Zhu, Jin Wu, Danyou Hu*, Yuwen Yan, andGuiyang Zhang*. Delivery of Small-Molecule Drugs and Protein Drugs by Injectable Acid-Responsive Self-Assembled COF Hydrogels for Combinatorial Lung Cancer Treatment.ACS Applied Materials & Interfaces2023, 15, 36, 42354-42368.  (IF: 8.5)

[9]Shengnan Zhou, Tian Tian, Tao Meng, Jin Wu, Danyou Hu, Qiaobo Liao, Jialu Zhuang, Hua Wang*, andGuiyang Zhang*. Tumor-derived covalent organic framework nanozymes for targeted chemo-photothermal combination therapy.iScience,2023, 26, 107348.  (IF: 4.6)

[10]英文著作章節(jié)撰寫(xiě): Covalent Organic Frameworks (ISBN 978-1-80356-960-4)2022, DOI: 10.5772/intechopen.102264 InTech Open. Chapter title: Applications of Covalent Organic Frameworks (COFs) in Oncotherapy. Authors: Dr. Guiyang Zhang*

專(zhuān)利與技術(shù)許可：

1.高杉;張貴陽(yáng);黃晨光;周勝南;李文雯COFs復(fù)合材料、緩釋體系及其在制備用于治療MI/R損傷的藥物中的應(yīng)用，專(zhuān)利號(hào)：ZL 2022 1 0062428.3

2.多孔復(fù)合材料長(zhǎng)效控糖體系、其制備方法和用途，高杉，張貴陽(yáng)，宋夢(mèng)夢(mèng)，王小云 專(zhuān)利號(hào)：ZL 2019 1 1069 108.52019

3.負(fù)載抗腫瘤藥物的納米復(fù)合材料、納米載藥體系及制備與應(yīng)用張貴陽(yáng)，胡丹優(yōu)，周勝南，朱玉恒，孟濤 專(zhuān)利號(hào)：ZL 2022 1 0795376.0