袁斌，校聘教授，博士生導(dǎo)師，東南博士后合作導(dǎo)師

在安徽醫(yī)科大學(xué)、北京生物工程研究所、德克薩斯大學(xué)圣安東尼奧健康科學(xué)中心獲得學(xué)士、碩士和博士學(xué)位，曾任喬治華盛頓大學(xué)醫(yī)學(xué)院研究助理教授。課題組借助腫瘤分子藥理學(xué)研究手段，結(jié)合體外細(xì)胞、體內(nèi)動(dòng)物模型和臨床樣本，重點(diǎn)關(guān)注腫瘤及其微環(huán)境中關(guān)鍵分子調(diào)控腫瘤發(fā)生、發(fā)展的分子機(jī)制，以及借助人工智能驅(qū)動(dòng)的深度學(xué)習(xí)模型篩選抗腫瘤藥物靶點(diǎn)、發(fā)現(xiàn)與設(shè)計(jì)抗腫瘤活性小分子化合物。在STTT（2024）、J Clin Invest（2014）、Science Advances（2019）、Journal for ImmunoTherapy of Cancer（2021）、Advanced Healthcare Materials（2024）、IJBS（2021）等SCI期刊上發(fā)表研究論文。獲得國(guó)家優(yōu)秀自費(fèi)留學(xué)生獎(jiǎng)學(xué)金，入選安徽省高層次創(chuàng)新創(chuàng)業(yè)引才項(xiàng)目。

研究方向：腫瘤分子藥理學(xué)

電子郵箱：yuanb_ahmu@163.com

辦公室：基礎(chǔ)樓418

部分代表性論文：

1. Yanni Lin#; Ling Li#;Bin Yuan#; Fei Luo#; Xiujuan Zhang#; Yuanjun Yang; Shaliu Luo; Jing Lin; Tianxing Ye; Youzhi Zhang; Shan Gao; Qinong Ye; Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1, Signal Transduct Target Ther. 2024, 9(1):337.

2. Saisai Ge#; Xinyue Wang#; Xinru Zhao; Lingling Yuan; Xuewei Bao; Caidie Sun; Zehua Gong; Jun Guo; Siyu Yuan; Danyou Hu; Jing Yang*;Bin Yuan*; Guiyang Zhang*; Responsive Multi-Arm PEG-Modified COF Nanocomposites: Dynamic Photothermal, pH/ROS Dual-Responsive, Targeted Carriers for Rheumatoid Arthritis Treatment, Adv Healthc Mater, 2024, e2401744.

3. Jing Yang; Leilei Qi; Huai-Chin Chiang; Bin Yuan*; Rong Li; Yanfen Hu*; BRCA1 Antibodies Matter, Int J Biol Sci. 2021, 17(12):3239-3254.

4.Bin Yuan; Curtis A Clark; Bogang Wu; Jing Yang; Justin M Drerup; Tianbao Li; Victor X Jin; Yanfen Hu; Tyler J Curiel*; Rong Li*; Estrogen receptor beta signaling in CD8+ T cells boosts T cell receptor activation and anti-tumor immunity through a phosphotyrosine switch, J Immunother Cancer, 2021, 9: e001932.

5. Long Cheng#;Bin Yuan#; Sunyang Ying#; Chang Niu#; Hongxu Mai; Xin Guan; Xiaohui Yang; Yan Teng; Jing Lin; Junjian Huang; RuiJin; Jun Wu; Bo Liu; Shaohong Chang; Enqun Wang; Chunxia Zhang; Ning Hou; Xuan Cheng; Danyang Xu; Xiao Yang*; Shan Gao*; Qinong Ye*; PES1 is a critical component of telomerase assembly and regulates cellular senescence, Sci Adv, 2019, 5(5): eaav1090.

6.Bin Yuan#; Long Cheng#; Huai-Chin Chiang; Xiaojie Xu; Yongjian Han; Hang Su; Lingxue Wang; Bo Zhang; Jing Lin; Xiaobing Li; XiangyangXie; Tao Wang; Rajeshwar R Tekmal; Tyler J Curiel; Zhi-Min Yuan; Richard Elledge; Yanfen Hu; Qinong Ye*; Rong Li*; A phosphotyrosine switch determines the antitumor activity of ERb, J Clin Invest, 2014, 124(8): 3378-3390.