李維祖，博士，教授，博士生導師

在安徽醫(yī)科大學藥學科學學院藥理學教研室從事教學和科研工作，2015年-2016年在美國北方德克薩斯大學健康科學中心做訪問學者一年。研究方向為神經(jīng)藥理學和內(nèi)分泌藥理學，主要從事老年性癡呆、II型糖尿病神經(jīng)系統(tǒng)和腎臟并發(fā)癥及人參皂苷Rg1的保護作用研究。近年來主持國家自然科學基金面上項目2項，主持安徽省自然科學基金重點項目1項，安徽省教育廳重大項目1項。發(fā)表SCI論文三十余篇，其中一篇論文被評為“安徽醫(yī)科大學2016年度最具影響力十佳論文”。承擔了安徽醫(yī)科大學臨床醫(yī)學專業(yè)、麻醉等專業(yè)、留學生的藥理學、麻醉藥理學等教學，2013和2023年獲安徽醫(yī)科大學優(yōu)秀教師榮譽稱號。

研究方向：神經(jīng)藥理學，包括阿爾茨海默病、糖尿病認知功能障礙等

電子郵箱：liweizu@126.com

主持課題項目情況：

1.安徽省科學技術(shù)廳,面上項目, 2208085MH219,基于PLC-CaN-NFAT1信號通路研究人參皂苷Rg1抑制神經(jīng)元Aβ生成的作用及機制, 2022-01至2024-12, 10萬元,資助期滿,主持。

2.安徽省高校自然科學研究重大項目，KJ2020ZD14，化藥1類新藥—HY-021068防治阿爾茨海默病的作用及機制研究，2021/01-2023/12，20萬元，已結(jié)題，主持。

3.國家自然科學基金面上項目，81671384，NADPH氧化酶介導的NLRP-1炎癥小體激活在腦老化認知功能障礙中的作用及人參皂苷Rg1的調(diào)節(jié)作用，2017/01-2018/12，25萬元，已結(jié)題，主持。

4.國家自然科學基金面上項目，81371329，糖皮質(zhì)激素對海馬神經(jīng)元NLRP1炎癥小體的調(diào)節(jié)作用及在海馬神經(jīng)元損傷中的作用，2014/01-2017/12，70萬元，已結(jié)題，主持。

發(fā)表論文情況：

1.Liangliang Kong, Yan Liu, Jingwei Li, Yanyan Wang, Pengmin Ji, Qifeng Shi, Min Han, Hanyang Xu, Weiping Li, Weizu Li. Ginsenoside Rg1 alleviates chronic inflammation-induced neuronal ferroptosis and cognitive impairments via regulation of AIM2 - Nrf2 signaling pathway.J Ethnopharmacol. 2024, 330:118205.

2.Huimin Zhou, Yan Liu, Yong Su, Pengmin Ji, Liangliang Kong, Ran Sun, Duoduo Zhang, Hanyang Xu, Weiping Li,Weizu Li. Ginsenoside Rg1 attenuates lipopolysaccharide-induced chronic liver damage by activating Nrf2 signaling and inhibiting inflammasomes in hepatic cells. J Ethnopharmacol. 2024, 324:117794.

3.Ye Huang, Min Han, Qifeng Shi, Xuewang Li, Jiajia Mo, Yan Liu, Zhaoxing Chu,Weizu Li. HY-021068 alleviates cerebral ischemia-reperfusion injury by inhibiting NLRP1 inflammasome and restoring autophagy function in mice.Exp Neurol. 2024, 371:114583.

4.Ran Sun, Min Han, Yan Liu, Yong Su, Qifeng Shi, Lei Huang, Liangliang Kong,Weizu Li, Weiping Li.Trpc6 knockout protects against renal fibrosis by restraining the CN NFAT2 signaling pathway in T2DM mice.Mol Med Rep. 2024, 29(1):13.

5.黃蕾，汪燕燕，孫冉，周慧敏，姬朋敏，孔亮亮，李衛(wèi)平，李維祖.人參皂苷Rg1通過抑制MAPK-NLRP1通路減輕2型糖尿病誘導的神經(jīng)元損傷.中國藥理學通報, 2023, 39(11):2034-2042.

6.Liangliang Kong, Ran Sun, Huimsin Zhou, Qifeng Shi, Yan Liu, Min Han, Weiping Li, Sen Qun,Weizu Li. Trpc6 knockout improves behavioral dysfunction and reduces Aβ production by inhibiting CN-NFAT1 signaling in T2DM mice. Exp Neurol. 2023, 363:114350.

7.Xuewang Li, Han Zhang, Liu Yang, Xianan Dong, Yuli Han, Yong Su, Weiping Li,Weizu Li. Inhibition of NLRP1 inflammasome improves autophagy dysfunction and Aβ disposition in APP/PS1 mice.Behav Brain Funct. 2023, 19(1):7.

8.Hu Xu,Weizu Li, Lei Huang, Xinyu He, Bei Xu, Xueqing He, Wentong Chen, Yaoxing Wang, Wenjun Xu, Sheng Wang, Qin Kong, Youzhi Xu, Wenjie Lu. Phosphoethanolamine cytidylyltransferase ameliorates mitochondrial function and apoptosis in hepatocytes in T2DM in vitro.J Lipid Res. 2023, 64(3):100337.

9.Yuli Han, Yong Su, Min Han, Yan Liu, Qifeng Shi, Xuewang Li, Penghui Wang, Weiping Li,Weizu Li. Ginsenoside Rg1 attenuates glomerular fibrosis by inhibiting CD36/TRPC6/NFAT2 signaling in type 2 diabetes mellitus mice.J Ethnopharmacol. 2023, 302(Pt A):115923.

10.Xianan Dong, Liangliang Kong, Lei Huang, Yong Su, Xuewang Li, Liu Yang, Pengmin Ji, Weiping Li,Weizu Li. Ginsenoside Rg1 treatment protects against cognitive dysfunction via inhibiting PLC-CN-NFAT1 signaling in T2DM mice.J Ginseng Res. 2023, 47(3):458-468.

11.Zhenghao Sun, Fei Liu, Liangliang Kong, Pengmin Ji, Lei Huang, Huimin Zhou, Ran Sun, Jing Luo,Weizu Li. Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm.Biomed Pharmacother. 2023, 161:114480.

12.Zhenghao Sun, Xuewang Li, Liu Yang, Xianan Dong, Yuli Han, Yan Li, Jing Luo,Weizu Li. SOCE-mediated NFAT1-NOX2-NLRP1 inflammasome involves in lipopolysaccharide-induced neuronal damage and Aa generation.Mol Neurobiol. 2022, 59(5):3183-3205.

13.Jing Luo, Xiaoqun Zhu, Fei Liu, Liang Zhao, Zhenghao Sun, Yan Li, Lei Ye,Weizu Li. Expression of serum miR-126 in patients with intracranial aneurysm and its relationship with postoperative cerebral vasospasm.Am J Transl Res. 2022, 14(6):4372-4379.

14.Yuli Han, Xuewang Li, Liu Yang, Duoduo Zhang, Lan Li, Xianan Dong, Yan Li, Sen Qun,Weizu Li. Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury due to inhibition of NOX2-mediated calcium homeostasis dysregulation in mice.J Ginseng Res. 2022, 46(4):515-525.

15.Shixin Ding, Liu Yang, Lei Huang, Liangliang Kong, Ming Chen, Yong Su, Xuewang Li, Xianan Dong, Yuli Han, Weiping Li,Weizu Li. Chronic glucocorticoid exposure accelerates Aβ generation and neurotoxicity by activating calcium-mediated CN-NFAT1 signaling in hippocampal neurons in APP/PS1 mice.Food Chem Toxicol. 2022, 168:113407.

16.Liu Yang, Huimin Zhou, Lei Huang, Yong Su, Liangliang Kong, Pengmin Ji, Ran Sun, Chao Wang, Weiping Li,Weizu Li. Stress level of glucocorticoid exacerbates neuronal damage and Aβ production through activating NLRP1 inflammasome in primary cultured hippocampal neurons of APP-PS1 mice.Int Immunopharmacol. 2022, 110:108972.