葉霽青，副研究員

研究方向：新藥分子設(shè)計、合成及生物活性研究

電子郵箱：jiqing_ye@ahmu.edu.cn

辦公室：知行樓B1513

教育經(jīng)歷：

(1) 2017/09-2020/09 香港理工大學(xué)，應(yīng)用生物與化學(xué)技術(shù)系，博士

(2) 2013/09-2016/06 中國藥科大學(xué),藥學(xué)院，碩士

(3) 2008/09-2013/07 安徽醫(yī)科大學(xué),藥學(xué)院，學(xué)士

工作經(jīng)歷：

(1) 2022/09-至今， 安徽醫(yī)科大學(xué)，校聘教授

(2) 2020/11-2022/12 化學(xué)生物學(xué)及藥物研發(fā)國家重點實驗室(香港理工大學(xué))，博后

(3)2016/07-2017/07 上海藥物研究所,研究助理

科研項目：

（1）國家自然科學(xué)基金委員會，青年科學(xué)基金項目，82304295，基于細(xì)菌RNAP-?蛋白-蛋白相互作用抑制劑SIGM-001的結(jié)構(gòu)優(yōu)化及抗菌活性研究，2024-01-01至2026-12-31，30萬元，在研，主持

發(fā)表論文情況：

1. Bingjie Li, Lixiu Xu, Chu Chen andJiqing Ye*, Mapping the Binding Hotspots and Transient Binding Pockets on V-Domain Immunoglobulin Suppressor of T Cell Activation Protein Surface.ACS Omega.,2024,9, 48657-48669.

2.Xiaowen Feng, Baoming Wu, Hanyang Xu, Chu Chen andJiqing Ye*. Virtual Screening and Biological Evaluation of Natural Products as Novel VPS34 Inhibitors that Modulate Autophagy.ChemMedChem.,2024, e202400580.

3.Jiqing Ye?, Cheuk Hei Kan?, Xiao Yang* and Cong Ma*. Inhibition of bacterial RNA polymerase function and protein–protein interactions: a promising approach for next-generation antibacterial therapeutics.RSC Med. Chem.,2024,15, 1471-1487.

4.Jiqing Ye?, Cheuk Hei Kan?, Yingbo Zheng, Tsz Fung Tsang, Adrian Jun Chu, King Hong Chan, Xiao Yang*, Cong Ma*. Sulfonamidyl derivatives of sigmacidin: Protein-protein interaction inhibitors targeting bacterial RNA polymerase and sigma factor interaction exhibiting antimicrobial activity against antibiotic-resistant bacteria.Bioorganic Chemistry.,2024,143, 106983.

5.Jiqing Ye, Xiao Yang*, Cong Ma*. Ligand-Based Drug Design of Novel Antimicrobials against Staphylococcus aureus by Targeting Bacterial Transcription.Int. J. Mol. Sci.,2023,24, 339.