邸磊，校聘副教授

研究方向：中藥活性成分鑒定及藥理活性機制研究；中藥大健康產(chǎn)品研發(fā)

電子郵箱：dilei@ahmu.edu.cn

辦公室：安徽醫(yī)科大學(xué) 知行樓B1111

教育經(jīng)歷：

(1) 2016/09-2019/06， 中國藥科大學(xué)，基礎(chǔ)醫(yī)學(xué)與臨床藥學(xué)學(xué)院，博士

(2) 2009/09-2012/06， 安徽大學(xué)，生命科學(xué)學(xué)院，碩士

(3) 2005/09-2009/06， 安徽大學(xué)，生命科學(xué)學(xué)院，學(xué)士

工作經(jīng)歷：

(1) 2019/07至今，安徽醫(yī)科大學(xué)，藥學(xué)科學(xué)學(xué)院，校聘副教授

(2) 2012/09-2016/06，中科院昆明植物研究所，研究實習(xí)員

科研項目：

（1）企業(yè)委托技術(shù)開發(fā)項目，基于經(jīng)典中藥方劑的藥食同源大健康產(chǎn)品開發(fā)，101萬，2025.01-2027.12

（2）企業(yè)委托技術(shù)開發(fā)項目，天然產(chǎn)物小鼠生殖毒性模型構(gòu)建，1萬，2024.07-2025.06

（3）安徽高校自然科學(xué)研究項目，重點項目黃花敗醬中新木脂素及其衍生物抗轉(zhuǎn)移性前列腺癌活性研，2021.01-2023.12，主持

發(fā)表論文情況：

1. Ren B, Li Y, Di L, Cheng R, Liu L, Li H, Li Y, Tang Z, Yan Y, Lu T, Fu R, Cheng Y, Wu Z. A naturally derived small molecule compound suppresses tumor growth and metastasis in mice by relieving p53-dependent repression of CDK2/Rb signaling and the Snail-driven EMT[J]. Chinese Journal of Natural Medicines, 2024, 22(2): 112-126.

2.Li Z, Xu Y, Sun X, Fan Z, Zhou Z, Ren F, Li N, Di L. Novel Iridoid Derivatives Isolated from the Roots ofPatrinia scabra with Potential Anti-Renal Fibrosis Activity In Vitro[J]. Molecules, 2024, 29(18): 4419.

3.Jiang M, Li L, Jin Y, Lu L, Lu Z, Lv W, Wang X, Di L, Liu Z. Derivative spectrophotometry-assisted determination of tryptophan metabolites emerges host and intestinal flora dysregulations during sepsis[J]. Anal Biochem, 2024, 694: 115605.

4.Yang Y, Li N, Wang TM, Di L. Natural Products with Activity against Lung Cancer: A Review Focusing on the Tumor Microenvironment[J]. Int J Mol Sci, 2021, 22(19): 10827.

5. Fu R, Han CF, Ni T, Di L, Liu LJ, Lv WC, Bi YR, Jiang N, He Y, Li HM, Wang S, Xie H, Chen BA, Wang XS, Weiss SJ, Lu T, Guo QL, Wu ZQ. A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours[J]. Nat Commun, 2019, 10(1): 3210.

6. Di L, Liu LJ, Yan YM, Fu R, Li Y, Xu Y, Cheng YX, Wu ZQ. Discovery of a natural small-molecule compound that suppresses tumor EMT, stemness and metastasis by inhibiting TGFbeta/BMP signaling in triple-negative breast cancer[J]. J Exp Clin Cancer Res, 2019, 38(1): 134.

7.Luo Q, Tian L, Di L, Yan YM, Wei XY, Wang XF, Cheng YX. (+/-)-Sinensilactam A, a pair of rare hybrid metabolites with Smad3 phosphorylation inhibition from Ganoderma sinensis[J]. Org Lett, 2015, 17(6): 1565-1568.

8.Luo Q, Di L, Dai WF, Lu Q, Yan YM, Yang ZL, Li RT, Cheng YX. Applanatumin A, a new dimeric meroterpenoid from Ganoderma applanatum that displays potent antifibrotic activity[J]. Org Lett, 2015, 17(5): 1110-1113.

9.Di L, Shi YN, Yan YM, Jiang LP, Hou B, Wang XL, Zuo ZL, Chen YB, Yang CP, Cheng YX. Nonpeptide small molecules from the insect Aspongopus chinensis and their neural stem cell proliferation stimulating properties[J]. RSC Advances, 2015, 5(87): 70985-70991.

10.Dou M, Di L, Zhou LL, Yan YM, Wang XL, Zhou FJ, Yang ZL, Li RT, Hou FF, Cheng YX. Cochlearols A and B, polycyclic meroterpenoids from the fungus Ganoderma cochlear that have renoprotective activities[J]. Org Lett, 2014, 16(23): 6064-6067.