宋玨，副教授

研究方向：藥物動力學(xué)、中藥藥理學(xué)、生物藥劑學(xué)

電子郵箱：bao712@126.com

辦公室：知行樓B座1215

教育經(jīng)歷：

(1) 2007/09至2012/06,安徽醫(yī)科大學(xué),藥理學(xué),博士

(2)2002/09至2005/06,中國藥科大學(xué),藥理學(xué),碩士

(3) 1997/09至2002/06,中國藥科大學(xué),藥理學(xué),學(xué)士

工作經(jīng)歷:

(1)2015/02至 今,安徽醫(yī)科大學(xué),藥學(xué)院藥劑學(xué)教研室,副教授

(2)2008/07至2015/01,安徽醫(yī)科大學(xué),藥學(xué)院藥劑學(xué)教研室,講師

(3) 2005/07至2008/06,安徽醫(yī)科大學(xué),藥學(xué)院藥劑學(xué)教研室,助教

科研項目:

(1)安徽省教育廳,安徽省高等學(xué)校科學(xué)研究項目重點(diǎn)科研項目, 2024AH050659,玉屏風(fēng)影響磷脂代謝重編程調(diào)控 肺慢性炎癥微環(huán)境中巨噬細(xì)胞極化的作用及機(jī)制研究, 2025-01至2026-12, 10萬元,在研,主持

(2)國家自然科學(xué)基金委員會,青年科學(xué)基金項目, 81803868,藥對“黃芪+白術(shù)”抗炎作用配伍增效的藥 動學(xué)分子機(jī)制及與藥物轉(zhuǎn)運(yùn)體SLC22As的相關(guān)性研究, 2019-01-01至2021-12-31, 21萬元,結(jié)題,主持

發(fā)表論文情況:

1.Dalang Li, Chuanzong Qi, Jian Zhou, Zeqiang Wen, Xiangyu Zhu, Hongguang Xia and Jue Song.LPS-induced inflammation delays the transportation of ASP + due to down-regulation of OCTN1/2 in alveolar epithelial cells.Journal of Drug Targeting.Published online: Oct 2019. ISSN1061-186X. 2020, 28( 4):437-447. (IF:5.123)

2.Chuanzong Qi, Jian Zhou, Zihao Wang, Xin Fang, Dalang Li, Yong Jin, Jue Song*.  Cigarette smoke extract combined with lipopolysaccharide reduces OCTN1/2 expression in human alveolar epithelial cells in vitro and rat lung in vivo under inflammatory conditions. International Immunopharmacology.2020. https://doi.org/10.1016/j.intimp.2020.106812 (IF: 4.932)

3.Jian Zhou, Chuanzong Qi, Xin Fang, Zihao Wang, Shuyi Zhang, Dalang Li, Jue Song. DJ-1 modulates Nrf2-mediated MRP1 expression by activating Wnt3a/β-catenin signalling in A549 cells exposed to cigarette smoke extract and LPS. Life Sciences, 276 (2021) :119089. doi: 10.1016/j.lfs.2021.119089 (IF:6.780 )

4.Xin Fang, Shuyi Zhang, Zihao Wang, Jian Zhou, Chuanzong Qi, Jue Song. Cigarette smoke extract combined with LPS down-regulates the expression of MRP2 in chronic pulmonary inflammation may be related to FXR. Molecular Immunology, 137 (2021) :174–186.   (IF:4.562)

5.Xin Fang, Zihao Wang, Chuanzong Qi, Jian Zhou a,b , Shuyi Zhang and Jue Song. The changes of MRP2 expression in three kinds of pulmonary inflammation models: the downregulation occurred in cigarette smoke extract (CSE) stimulation group and CSE plus LPS stimulation group, unchanged in LPS stimulation group. Toxicology Mechanisms And Methods, 2021, 31(6):413-424 . (IF: 2.885)

6.Zihao Wang,Xin Fang,Shuyi Zhang,Jue Song.Pulmonary inflammation caused by cigarette smoke combined with lipopolysaccharide up-regulated OATP2B1 in rat lung tissue and pulmonary epithelial cells. Experimental Lung Research. 2022, 48(3):114-125. (IF: 1.7)

7.Shuyi Zhang, Xianwang Lu, Xin Fang, Zihao Wang, Shihao Cheng, Jue Song. Cigarette smoke extract combined with LPS reduces ABCA3 expression in chronic pulmonary inflammation may be related to PPARγ/ P38 MAPK signaling pathway. Ecotoxicology and Environmental Safety.2022, 244:114086 (IF: 6.8)

8.聞澤強(qiáng)，李大朗，宋玨.玉屏風(fēng)水煎劑及其組分對大鼠腎臟組織及HEK-293細(xì)胞OATl/3表達(dá)的影響.中成藥. 2020, 42(6): 1457-1462.