湯繼輝，教授

研究方向：藥物新劑型與新制劑、新型給藥系統(tǒng)的研究

電子郵箱：tangjh@ahmu.edu.cn

辦公室：知行樓B1213

教育經(jīng)歷：

(1) 2009/09-2012/06， 中國藥科大學(xué)，藥學(xué)院，博士

(2)2003/09-2006/06，安徽中醫(yī)藥大學(xué)，藥學(xué)院，碩士

(3)1999/09-2003/06，安徽中醫(yī)藥大學(xué)，藥學(xué)院，學(xué)士

工作經(jīng)歷：

(1)2022/12至 今，安徽醫(yī)科大學(xué)，藥學(xué)院，教授

(2) 2016/09- 2022/12，安徽醫(yī)科大學(xué)，藥學(xué)院，副教授

(3)2013/09-2016/02,安徽醫(yī)科大學(xué),博士后

(4) 2009/07-2016/08，安徽醫(yī)科大學(xué)，藥學(xué)院，講師

(5) 2006/06-2009/06， 安徽醫(yī)科大學(xué)，藥學(xué)院， 助教

學(xué)術(shù)榮譽(yù)：安徽省學(xué)科（專業(yè)）帶頭人培育人選

學(xué)術(shù)兼職：2020/03，《現(xiàn)代藥物靶點(diǎn)（Current Drug Targets）》的客座編輯

科研項(xiàng)目：

1.安徽省自然科學(xué)基金面上項(xiàng)目：基于“Dont eat me”信號構(gòu)建的免疫逃逸納米制劑提高腫瘤光動力治療效果及其機(jī)制研究（2308085MH308），2023.9-2026.8，10萬元，在研主持

2.安徽省藥品監(jiān)管科學(xué)研究重點(diǎn)項(xiàng)目：基于藥物吸收建立的新型溶出方法及其用于藥物質(zhì)量監(jiān)測的研究（AHYJ-KJ-202206），2023.1-2024.12，10萬元，結(jié)題，主持

3.安徽高校自然科學(xué)研究項(xiàng)目：基于磷脂酰絲氨酸特異性識別肽及pH敏感雙靶向制劑的研究（KJ2020A0157），2021.01-2023.12，6萬元，結(jié)題，主持

4.新安醫(yī)學(xué)教育部重點(diǎn)實(shí)驗(yàn)室開放基金：中藥桔梗對荊芥載藥上浮作用物質(zhì)基礎(chǔ)及機(jī)制研究（2020xayx02），2021.01-2023.12，6萬元，結(jié)題，主持

5.國家自然科學(xué)基金青年基金：針對腫瘤細(xì)胞周期的時相靶向制劑的研究（81503004），2016.01-2018.12，17.9萬元，結(jié)題，主持

6.安徽省自然科學(xué)基金青年項(xiàng)目：基于葉酸修飾聚合物膠束的細(xì)胞周期特異性靶向給藥系統(tǒng)的研究（1408085QH189），2014/07-2016/06，7萬元，結(jié)題，主持

7.安徽省高校省級優(yōu)秀人才基金重點(diǎn)項(xiàng)目：葉酸修飾聚氨基酸膠束主動靶向給藥系統(tǒng)的研究（2013SQRL019ZD），2014/01-2016/12，9萬元，結(jié)題，主持

發(fā)表論文情況：

1.Lele Wang, Tijie Duan, Yawen Gao,Heqing Liu, Rui Sun,Tong Wu, Jihui Tang*. Development and in vitro-in vivo evaluation of a novel sustained-release tablet based on constant-release surface.Journal of Drug Delivery Science and Technology, 2025, 105

2.Minxing Hu, Jianwei Bao, Yuanmei Zhang, Lele Wang, Ya Zhang, Jiaxin Zhang, Jihui Tang*, Qianli Zou*.Supramolecular Nanoparticles of Histone and Hyaluronic Acid for Co-Delivery of siRNA and Photosensitizer In Vitro.International Journal Of Molecular Sciences.2024,25(10):5424.

3.Yuji Xin, Yixuan Zou, Hanfang Lei, Yong Bi, Rui Yang, Jihui Tang*, Qingri Jin*.

Advances in Cyclodextrins and Their Derivatives in Nano-Delivery Systems.Pharmaceutics. 2024,16(8):1054.

4.Yawen Gao, Lele Wang, Xue Zhang, Ziling Zhou, Xinzhu Shen, Haodong Hu, Rui Sun, Jihui Tang*. Advances in Self-Assembled Peptides as Drug Carriers.Pharmaceutics.2023，15(2):482.

5.Jianwei Bao, Minxing Hu, Yuanmei Zhang, Qianqian Zhang, Feiyan Zhu, Qianli Zou*,Jihui Tang*. Novel active stealth micelles based on β2M achieved effective antitumor therapy.Biomedicine & Pharmacotherapy. 2022，151，113175.

6.Qianqian Zhang, Jianwei Bao, Tijie Duan, Minxing Hu, Yuting He, Junwei Wang, Rongfeng Hu*,Jihui Tang*. Nanomicelle-Microsphere Composite as a Drug Carrier to Improve Lung-Targeting Specificity for Lung Cancer,Pharmaceutics, 2022, 14(3): 510

7.Bo Li, Tingfei Tan, Weiwei Chu, Ying Zhang, Yuanzi Ye, Shanshan Wang, Yan Qin,Jihui Tang*, Xi Cao*. Co-delivery of paclitaxel (PTX) and docosahexaenoic acid (DHA) by targeting lipid nanoemulsions for cancer therapy.Drug Delivery, 2022, 29 (1):75-78.

8.Jianwei Bao, Qianqian Zhang, Tijie Duan,Rongfeng Hu,Jihui Tang*. The Fate of Nanoparticles In Vivo and the Strategy of Designing Stealth Nanoparticle for Drug Delivery.Curr Drug Targets, 2021,22(8):922-946

9.Siyu Guan, Qianqian Zhang, Jianwei Bao, Tijie Duan, Rongfeng Hu, Tori Czech,Jihui Tang*.Phosphatidylserine targeting peptide-functionalized pH sensitive mixed micelles for enhanced anti-tumor drug delivery.European Journal of Pharmaceutics and Biopharmaceutics. 2020,147:87-101.

10.Siyu Guan, Qianqian Zhang, Jianwei Bao, Rongfeng Hu, Tori Czech,Jihui Tang *.Recognition Sites for Cancer-targeting Drug Delivery Systems.Current Drug Metabolism. 2019;20(10):815-834.

11.Jihui Tang*, Jie Ning, Xiaoyan Liu, Baoming Wu, Rongfeng Hu*. A Novel Amino Acid Sequence-based Computational Approach to Predicting Cell-penetrating Peptides.Current computer-aided drug design. 2019,15(3):206-211.

12.Wenxiu Hong, Rongfeng Hu, Xuechao Huang, Xiaoqian Lu, Tori Czech,Jihui Tang*. In vivo pharmacokinetics and biodistribution of novel all-trans retinoic acid derivative-loaded, folate-modified poly (L-amino acid) micelles.Journal of Drug Delivery Science & Technology. 2017, 41: 436-43.

13.Jihui Tang, Ziwei Liu, Fenqi Ji, Yao Li, Junjie Liu, Jian Song, Jun Li*, Jianping Zhou*. The role of the cell cycle in the cellular uptake of folate-modified poly (L-amino acid) micelles in a cell population.Nanoscale. 2015, 7(48): 20397-404.

14.Jihui Tang*, Xinqun Wang, Ting Wang, Feihu Chen, Jianping Zhou. In vivo pharmacokinetics, biodistribution and antitumor effect of amphiphilic poly(L-amino acids) micelles loaded with a novel all-trans retinoic acid derivative.European Journal of Pharmaceutical Sciences, 2014, 51(1): 157-64.

發(fā)表專利情況：

1）湯繼輝;鄒千里;鮑健威;一種免疫逃逸納米制劑、制備方法及應(yīng)用, 2021-12-13,中國, ZL 20211 1522727.2

2)湯繼輝，韓治敏，何佳琪，柳圓圓，鄭層層.一種紫杉醇粉霧劑的制備方法，中國專利：ZL201810603428.3（授權(quán)）

3)湯繼輝，李俊，劉紫薇，宋見，紀(jì)玢琪，李瑤，劉俊節(jié).一種腫瘤靶向聚合物膠束及其制備方法，2017.10.27，中國：ZL201510475783.3（授權(quán)）