葛金芳，教授

研究方向：神經(jīng)藥理學(xué)

電子郵箱：gejinfang@ahmu.edu.cn

辦公室：知行樓B座1505室

教育經(jīng)歷：

1.2006/09 - 2012/11,中國科學(xué)技術(shù)大學(xué),神經(jīng)生物學(xué),博士

2.2001/09 - 2004/06,安徽醫(yī)科大學(xué),藥理學(xué),碩士

工作經(jīng)歷：

1.2017-12至今,安徽醫(yī)科大學(xué),藥學(xué)院,教授

2.2018/08 - 2019/08,美國東北俄亥俄醫(yī)科大學(xué),藥學(xué)院,訪學(xué)

3.2012/07 - 2017/11,安徽醫(yī)科大學(xué),藥學(xué)院,副教授

4.2014/01 - 2014/02,澳大利亞塔斯馬尼亞大學(xué),藥學(xué)院,訪學(xué)

5.2006/07 - 2012/06,安徽醫(yī)科大學(xué),藥學(xué)院,講師

6.2004/07 - 2006/06,安徽醫(yī)科大學(xué),藥學(xué)院,助教

7.1992/06-2001/08，安徽醫(yī)科大學(xué)，第一附屬醫(yī)院

近5年學(xué)術(shù)榮譽：

1.安徽省教學(xué)成果二等獎（第一完成人，2024）

2.安徽省教學(xué)成果一等獎（第一完成人，2020）

3.安徽省教學(xué)創(chuàng)新團(tuán)隊負(fù)責(zé)人（2023）

4.安徽省教學(xué)名師（2022）

5.安徽醫(yī)科大學(xué)十佳基礎(chǔ)教師（2023）

6.安徽醫(yī)科大學(xué)悅?cè)菏褎?chuàng)新科技工作者 （2022）

7.安徽醫(yī)科大學(xué)教學(xué)貢獻(xiàn)新華獎（2020）

8.安徽醫(yī)科大學(xué)優(yōu)秀研究生導(dǎo)師（2020）

9.2023、2024年度“全球前2%頂尖科學(xué)家榜單”

10.學(xué)術(shù)兼職中國藥學(xué)會、中國藥理學(xué)會、中國神經(jīng)科學(xué)學(xué)會會員。

近5年主持課題項目情況：

1.國家自然科學(xué)基金面上項目（81870403）：Nesfatin-1通過肝-腦軸固有巨噬細(xì)胞miRNA-34a- TREM2/DAP12- Wnt/ β-catenin信號通路調(diào)控NAFLD大鼠的脂質(zhì)代謝紊亂及神經(jīng)精神行為異常，2019-2022年，已結(jié)題，主持

2.安徽省高等學(xué)校科學(xué)研究重點項目（2024AH050773）：線粒體動力蛋白Drp1驅(qū)動的海馬小膠質(zhì)細(xì)胞線粒體穩(wěn)態(tài)失衡在抑郁癥發(fā)病機制中的作用，2025-2026，在研，主持

3.安徽省高校學(xué)科（專業(yè)）拔尖人才學(xué)術(shù)資助項目（gxbjZD2022013）：松果體素通過調(diào)節(jié)海馬小膠質(zhì)細(xì)胞BMAIL/CLOCK-BDNF- TREM2-Wnt/β-catenin信號通路改善NAFLD大鼠的神經(jīng)精神損傷，2022年-2024年，已結(jié)題，主持

4.安徽省高校合作攻關(guān)和公共衛(wèi)生協(xié)同創(chuàng)新重點科研平臺支持項目（GXXT-2020-062）：抗癲癇γ-氨基丁酸(GABA)類似物的合成、生物活性及成藥性研究，2020-2022年，已結(jié)題，主持

5.安徽醫(yī)科大學(xué)科研水平提升計劃（2022xkjT009）：褪黑素通過調(diào)節(jié)VMH-SCN-vHPC神經(jīng)環(huán)路改善T2DM晝夜節(jié)律紊亂及認(rèn)知功能損傷，2023年-2025年，在研，主持

近5年發(fā)表論文情況：

1.Ma MD，F(xiàn)an M, Xu SL, Zheng Q, Wang CY, Chen PQ, Wei YD, Ge JF (通訊作者). Melatonin alleviates the retinal injury induced by vigabatrin and partly enhances its antiepileptic effects. Int Immunopharmacol. 2025 Apr 21;153: 114516.

2.Zheng Q, Xu SL, Guo XL, Wang CY, Ma MD, Ge JF (通訊作者). Effects of melatonin on the pharmacokinetics and amino acid metabolism profile of vigabatrin in rats. Toxicol Appl Pharmacol. 2025 Jan 28:117247

3.Sun HZ, Gao X, Niu JC, Chen PQ, He S, Xu SL, Ge JF (通訊作者). AD-like neuropsychiatric dysfunction in a mice model induced by a combination of high-fat diet and intraperitoneal injection of streptozotocin. eNeuro. 2024 Dec 3: ENEURO. 0310-24.2024.

4.Gao WF, Gao YJ, Xu YY, Liang J, Sun YH, Zhang YY, Shan F, Ge JF (共同通訊作者), Xia QR. Effect of duloxetine on changes in serum proinflammatory cytokine levels in patients with major depressive disorder. BMC Psychiatry. 2024 Jun 14;24(1):449. 

5.Gao YJ, Ling Y, Li J, Xu YY, Ge JF (共同通訊作者), Xia QR. Neuropathological implication of high blood bilirubin in patients and model rats with depression. Brain Res Bull. 2024 Jul 9:111028. 

6.Gao XR, Sun HZ, Wei YD, Hao SW, Niu JC, Sun HM, Tang GZ, Qi CC, Ge JF (通訊作者). Protective effect of melatonin against metabolic disorders and neuropsychiatric injuries in type 2 diabetes mellitus mice. Phytomedicine. 2024 Jun 4:131:155805.

7.He S, Yu Y, Chen P Q, Sun HM, Gao XR, Sun HZ, Ge JF (通訊作者).  Insufficient plasma melatonin and its association with neuropsychiatric impairments in patients with T2DM. J Diabetes Res. 2024 Jul 3; 2024:5661751. 

8.Xu SL, Fan M, Ma MD, Zheng Q, Chen PQ, Wei YD, Sun HM, Sun HZ, Ge JF (通訊作者). Differential toxic and antiepileptic features of Vigabatrin raceme and its enantiomers. Brain Res. 2024 May 14; 1838:148991. 

9.Xu DD, Hou ZQ, Xu YY, Liang J, Gao YJ, Zhang C, Guo F, Huang DD, Ge JF (通訊作者), Xia QR. Potential role of Bmal1 in Lipopolysaccharide-Induced Depression-like behavior and its associated "Inflammatory Storm". J Neuroimmune Pharmacol. 2024; 19, 4

10.Zheng Q, He S, Xu SL, Ma MD, Fan M, Ge JF (通訊作者). Pharmacokinetics and tissue distribution of vigabatrin enantiomers in rats. Saudi Pharm J. 2024 Feb;32(2):101934.

11.Li Q, Wang HX, Yang QL, Zhang L, Dai FC, Yu LJ, Wu L, Ge JF (共同通訊作者), Zhu P. Association of gestational cardiovascular health with infant neurodevelopment: A prospective study in Hefei of Anhui, China. Prev Med Rep. 2024 Jan 3; 38:102586. 

12.Ma RR, Wang P, Yang QL, Zhu YY, Zhang L, Wang YH, Sun LJ, Li WX, Ge JF (共同通訊作者), Zhu P. Interpregnancy interval and early infant neurodevelopment: the role of maternal-fetal glucose metabolism. BMC Med. 2024 Jan 2;22(1):2.

13.Li Q, Wang HX, Sun LJ, Wang P, Yin WJ, Ma SS, Tao RX, Ge JF (共同通訊作者), Zhu P. The mediating role of inflammation in the association between pregnancy loss history and gestational diabetes mellitus. Diabetol Metab Syndr. 2023 Jun 21;15(1):132.

14.Gao XR, Sun HZ, Hao SW, Sun HM, Ge JF (通訊作者). Melatonin protects HT-22 cells against palmitic acid-induced glucolipid metabolic dysfunction and cell injuries: Involved in the regulation of synaptic plasticity and circadian rhythms, Biochem Pharmacol. 2023 Oct 5: 115846.

15.Xu DD, Xu YY, Gao XR, Yan MY, Zhang C, Wu X, Xia QR, Ge JF (通訊作者). Potential value of Interleukin-6 as a diagnostic biomarker in human MDD and the antidepressant effect of its receptor antagonist tocilizumab in lipopolysaccharide-challenged rats. Int Immunopharmacol. 2023 Sep 15;124 (Pt B):110903.

16.Gao XR, Wei YD, Sun HZ, Hao SW, Ma MD, Sun HM, Zang DD, Qi CC, Ge JF (通訊作者). Role of Bmal1 in Type 2 Diabetes Mellitus-Related Glycolipid Metabolic Disorder and Neuropsychiatric Injury: Involved in the Regulation of Synaptic Plasticity and Circadian Rhythms. Mol Neurobiol. 2023 Aug; 60(8): 4595-4617.

17.Zheng Q, Han YX, Fan M, Gao XR, Ma MD, Xu JX, Liu S, Ge JF (通訊作者). Potential role of TREM2 in high cholesterolinduced cell injury and metabolic dysfunction in SHSY5Y cells. Exp Ther Med 2023 25: 205

18.Xu YY, Liang J, Sun YH, Zhang YY, Shan F, Ge JF (共同通訊作者), Xia QR. Serum cytokines-based biomarkers in the diagnosis and monitoring of therapeutic response in patients with major depressive disorder. Int Immunopharmacol. 2023 Mar 31; 118:110108. 

19.Ma SS, Yin WJ, Wang P, Wang HX, Zhang L, Jiang XM, Zhang Y, Tao RX, Ge JF (共同通訊作者), Zhu P. Previous pregnancy loss and gestational cardiovascular health: A prospective cohort of nulliparous women. Front Public Health. 2023 Apr 11; 11:1071706.

20.Sun HM, Yu Y, Gao XR, Wei YD, Qi CZ, Ma MD, Xu DD, Xu YY, Ge JF (通訊作者). Potential role of 25(OH)D insufficiency in the dysfunction of glycolipid metabolism and cognitive impairment in patients with T2DM. Frontiers in endocrinology. 2022 Dec 23;13: 1068199.

21..Liu S, Fan M, Ma MD, Ge JF (通訊作者). Chen FH. Long non-coding RNAs: Potential therapeutic targets for epilepsy. Front Neurosci. 2022 Oct 6;16: 986874.

22.Liu S , Fan M , Xu JX, Yang LJ, Qi CC, Xia QR, Ge JF (通訊作者). Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology. J Neuroinflammation. 2022;19(1):35. (ESI高被引論文)

23.Liu S, Fan M, Zheng Q, Hao SW, Yang LJ, Xia QR, Qi CC, Ge JF (通訊作者). MicroRNAs in Alzheimer's disease: potential diagnostic markers and therapeutic targets. Biomedicine & Pharmacotherapy. 2022;112681. (ESI高被引論文)

24.Fan M, Liu S, Sun HM, Ma MD, Gao YJ, Qi CC, Xia QR, Ge JF (通訊作者). Bilateral intracerebroventricular injection of streptozotocin induces AD-like behavioral impairments and neuropathological features in mice: Involved with the fundamental role of neuroinflammation.  Biomedicine & Pharmacotherapy. 2022;113375.

25.Wei YD, Chen XX, Yang LJ, Gao XR, Xia QR, Qi CC, Ge JF (通訊作者). Resveratrol ameliorates learning and memory impairments induced by bilateral hippocampal injection of streptozotocin in mice. Neurochem Int. 2022 Jul 14:105385.

26.Gao WF, Xu YY, Liang J, Sun YH, Zhang YY, Shan F, Ge JF (共同通訊作者), Xia QR. Comparison of serum cytokines levels in normal-weight and overweight patients with first-episode drug-na?ve major depressive disorder. Front. Endocrinol. 2022; 13:1048337

27.Xu YY, Liang J, Gao WF, Sun YH, Zhang YY, Shan F, Ge JF (共同通訊作者), Xia QR. Peripheral blood cytokines as potential diagnostic biomarkers of suicidal ideation in patients with first-episode drug-na?ve major depressive disorder. Front. Public Health. 2022; 10:1021309

28.Gao WF, Xu YY, Liang J, Sun YH, Zhang YY, Shan F, Ge JF (共同通訊作者), Xia QR. Serum CC Chemokines as Potential Biomarkers for the Diagnosis of Major Depressive Disorder. Psychology Research and Behavior Management 2022:15

29.Xu DD, Yu Y, Xu YY, Ge JF (通訊作者). Plasma Nesfatin-1: Potential Predictor and Diagnostic Biomarker for Cognitive Dysfunction in T2DM Patient. Diabetes Metab Syndr Obes. 2021 Aug 10; 14:3555-3566. 

30.Gao XR, Chen Z, Fang K, Xu JX, Ge JF (通訊作者). Protective effect of quercetin against the metabolic dysfunction of glucose and lipids and its associated learning and memory impairments in NAFLD rats. Lipids in Health and Disease 2021; 20:164.

31.Xu JX, Fang K, Gao XR, Liu S, Ge JF (通訊作者). Resveratrol Protects SHSY5Y Cells Against Oleic AcidInduced Glucolipid Metabolic Dysfunction and Cell Injuries Via the Wnt/βCatenin Signalling Pathway. Neurochem Res. 2021; 46:2936-2947

32.Qi CC, Chen XX, Gao XR, Xu JX, Liu S, Ge JF (通訊作者). Impaired Learning and Memory Ability Induced by a Bilaterally Hippocampal Injection of Streptozotocin in Mice: Involved With the Adaptive Changes of Synaptic Plasticity. Front. Aging Neurosci. 2021 May 1; 13: 633495.

33.馬夢蝶，樊敏，徐松林，鄭強，何帥，葛金芳（通訊作者）．紅藻氨酸誘導(dǎo)大鼠癲癇發(fā)作及神經(jīng)精神行為異常的性別差異．中國實驗動物學(xué)報, 2024,

34.方可，劉猛，葛金芳（通訊作者）.外泌體miRNA在雙相情感障礙中的作用及其診斷和治療潛力.中華精神科雜志, 2024, 57(5):274-281

35.鄭強，樊敏，葛金芳（通訊作者）.氨己烯酸的作用機制及代謝分布研究進(jìn)展.中國新藥雜志,2023,32(13):1351-1357.

36.高欣冉，葛金芳（通訊作者）.腦源性神經(jīng)營養(yǎng)因子在2型糖尿病認(rèn)知功能障礙機制中作用的研究進(jìn)展.中國糖尿病雜志,2022,30(04):305-309.

37.劉森，葛金芳（通訊作者）.外泌體在2型糖尿病發(fā)病機制及診療標(biāo)志物開發(fā)中的研究進(jìn)展.中國新藥雜志. 2022. 31(03): 237-244.

38.徐靜嫻，劉森，高欣冉，高葉俊，夏清榮，葛金芳（通訊作者）.白藜蘆醇通過調(diào)節(jié)BDNF/Akt/CREB及TREM1/2表達(dá)失衡抑制脂多糖誘導(dǎo)的BV2小膠質(zhì)細(xì)胞炎癥反應(yīng).中國藥理學(xué)通報. 2021, 37(10): 1402-1408.

39.劉森，陳征，高欣冉，彭磊，葛金芳（通訊作者）.高脂飲食對大鼠海馬形態(tài)及突觸相關(guān)蛋白Synapsin-1表達(dá)的影響.安徽醫(yī)科大學(xué)學(xué)報. 2021; 56(06):862-866.

近5年授權(quán)專利情況:

1.葛金芳，陳飛虎，樊敏，鄭強，馬夢蝶，高欣冉，徐松林，何帥.褪黑素在制備抗癲癇藥物中的應(yīng)用及制備的抗癲癇和改善視網(wǎng)膜毒性的藥物.中華人民共和國國家知識產(chǎn)權(quán)局發(fā)明專利申請，專利號：202211509837.X，授權(quán)公告日：2024年04月30日，授權(quán)公告號：CN 115737640 B