李榮，教授

研究方向：類風(fēng)濕關(guān)節(jié)炎發(fā)病機(jī)制；類風(fēng)濕關(guān)節(jié)炎藥物治療機(jī)制

電子郵箱：lirong@ahmu.edu.cn

辦公室：知行樓B1105

教育經(jīng)歷：

(1) 2007/09-2010/06，安徽醫(yī)科大學(xué)，藥學(xué)科學(xué)學(xué)院，博士

(2) 2003/09-2006/06，安徽醫(yī)科大學(xué)，藥學(xué)科學(xué)學(xué)院，碩士

(3) 1997/09-2001/06，山東大學(xué)，藥學(xué)院，學(xué)士

工作經(jīng)歷：

(1) 2018/01至今，安徽醫(yī)科大學(xué)，藥學(xué)科學(xué)學(xué)院，教授

(2) 2011/09-2017/12，安徽醫(yī)科大學(xué)，藥學(xué)科學(xué)學(xué)院，副教授

(3) 2006/09-2011/08，安徽醫(yī)科大學(xué)，藥學(xué)科學(xué)學(xué)院，講師

(4) 2001/07-2006/08，安徽醫(yī)科大學(xué)，藥學(xué)科學(xué)學(xué)院，助教

學(xué)術(shù)榮譽(yù)：

2024/01，安徽省教育廳“學(xué)科（專業(yè)）帶頭人培育人選”

2013/03，安徽醫(yī)科大學(xué)“中青年學(xué)術(shù)技術(shù)帶頭人”

科研項目：

（1）安徽省教育廳，高校中青年教師培養(yǎng)行動“學(xué)科（專業(yè)）帶頭人培育項目”，DTR2023010，AQP1調(diào)控β-catenin/NLRP3炎癥小體通路介導(dǎo)的FLS焦亡在類風(fēng)濕關(guān)節(jié)炎發(fā)病機(jī)制中的研究，2024.01-2026.12，10萬元，在研，主持

（2）安徽醫(yī)科大學(xué)，科研水平提升計劃項目，2022xkjT008，c-Jun/AQP1/Beclin1軸介導(dǎo)FLS自噬上調(diào)促進(jìn)類風(fēng)濕關(guān)節(jié)炎滑膜增生和滑膜炎癥的機(jī)制研究，2023.01-2025.12，30萬元，在研，主持

（3）安徽省教育廳，高校與合肥綜合性國家科學(xué)中心協(xié)同創(chuàng)新項目，GXXT-2022-063，水通道蛋白1通過誘導(dǎo)自噬促進(jìn)類風(fēng)濕關(guān)節(jié)炎成纖維樣滑膜細(xì)胞增殖和炎癥的機(jī)制研究及靶向藥物發(fā)現(xiàn)，2023.01-2024.12，50萬元，結(jié)題，主持

（4）國家自然科學(xué)基金委員會，面上項目，81972040，水通道蛋白1通過Wnt/β-catenin通路調(diào)控FLS活化參與類風(fēng)濕關(guān)節(jié)炎發(fā)病的機(jī)制研究，2020.01-2023.12，55萬元，結(jié)題，主持

（5）安徽省教育廳，高校優(yōu)秀青年人才支持計劃重點項目，gxyqZD2016045，水通道蛋白4參與類風(fēng)濕關(guān)節(jié)炎關(guān)節(jié)軟骨損傷的機(jī)制和功能研究，2016.01-2018.12，6萬元，結(jié)題，主持

（6）國家自然科學(xué)基金委員會，青年科學(xué)基金項目，81102273，Hedgehog-GLi1信號通路在類風(fēng)濕關(guān)節(jié)炎關(guān)節(jié)軟骨損傷和修復(fù)中的作用及機(jī)制研究，2012.01-2014.12，24萬元，結(jié)題，主持

教學(xué)項目：

安徽省教育廳，高等學(xué)校省級質(zhì)量工程項目，2022xxkc056，藥物化學(xué)線下課程，2023.04-2025.04，3萬元，在研，主持

發(fā)表論文情況：

1. Zhang, Man-yu#; Wang, Meng-qing#; Huang, Yan; Gu, Sheng-long; Zhou, Meng-yuan; Xu, Ze-shan; Li, Ling-ling; Lv, Min; Cai, Li*; Li, Rong*. Silencing aquaporin 1 inhibits autophagy to exert anti-rheumatoid arthritis effects in TNF-alpha-induced fibroblast-like synoviocytes and adjuvant-induced arthritis rats.Inflammation Research,2025, 74(1): 12.

2. Huang, Yan#; Zhou, Meng-yuan#; Li, Ling-ling; Lv, Min; Xu, Ze-shan; Wu, Xin-jie; Gu, Sheng-long; Zhang, Man-yu; Cai, Li*; Li, Rong*. Bacopaside I, acting as an aquaporin 1 inhibitor, ameliorates rheumatoid arthritis via suppressing aquaporin 1-mediated autophagy.Phytomedicine,2025, 138: 156444.

3. Gu, Sheng-long#; Liu, Xue-song#; Xu, Ze-shan; Li, Ling-ling; Wu, Xin-jie; Li, Fei-long; Huang, Yan; Ran, Xiang*; Li, Rong*. Eupalinolide B alleviates rheumatoid arthritis through the promotion of apoptosis and autophagy via regulating the AMPK/mTOR/ULK-1 signaling axis.International Immunopharmacology,2025, 148: 114179.

4. Jiang, Fei#; Wang, Meng-qing#; Zhang, Man-yu; Gu, Sheng-long; Xie, Ya-wen; Huang, Yan; Zhou, Meng-yuan; Li, Fei-long; Yang, Yu-chen; Zhang, Pei-pei; Liu, Xue-song*; Li, Rong*. CPD-002, a novel VEGFR2 inhibitor, relieves rheumatoid arthritis by reducing angiogenesis through the suppression of the VEGFR2/PI3K/AKT signaling pathway.International Immunopharmacology,2024, 131: 111850.

5. Liu, Fang-yuan#; Wang, Meng-qing#; Liu, Ming-ming#; Li, Tao; Wang, Xiao-hua; Jiang, Fei; Wu, Xin-jie; Cheng, Juan; Cai, Li*; Li, Rong*. Therapeutic effects of shikonin on adjuvant-induced arthritis in rats and cellular inflammation, migration and invasion of rheumatoid fibroblast-like synoviocytes via blocking the activation of Wnt/beta-catenin pathway.Phytomedicine,2023, 116: 154857.

6. Cai, Li#; Meng, Bo#; Jiang, Fei#; Shu, Wen-hao; Wang, Xiao-hua; Wang, Meng-qing; Wu, Xin-jie; Hu, Ming-wang; Yang, Yu-chen; Ran, Xiang*; Li, Rong*. Novel HIF-1alpha Inhibitor AMSP-30m Mitigates the Pathogenic Cellular Behaviors of Hypoxia-Stimulated Fibroblast-Like Synoviocytes and Alleviates Collagen-Induced Arthritis in Rats via Inhibiting Sonic Hedgehog Pathway.Inflammation,2023, 46(6): 2289-2305.

7. Cai, Li#; Zong, Pan#; Zhou, Meng-yuan; Liu, Fang-yuan; Meng, Bo; Liu, Ming-ming*; Li, Zeng*; Li, Rong*. 7-Hydroxycoumarin mitigates the severity of collagen-induced arthritis in rats by inhibiting proliferation and inducing apoptosis of fibroblast-like synoviocytes via suppression of Wnt/beta-catenin signaling pathway.Phytomedicine,2022, 94: 153841.

8. Cai, Li#; Zhou, Meng-yuan#; Hu, Shuang#; Liu, Fang-yuan; Wang, Meng-qing; Wang, Xiao-hua; Jiang, Fei; Feng, Xiao-wen; Liu, Xue-song; Li, Rong*. Umbelliferone Inhibits Migration, Invasion and Inflammation of Rheumatoid Arthritis Fibroblast-Like Synoviocytes and Relieves Adjuvant-Induced Arthritis in Rats by Blockade of Wnt/beta-Catenin Signaling Pathway.American Journal of Chinese Medicine,2022, 50(7): 1945-1962.

9. Zhou, Meng-yuan#; Cai, Li#; Feng, Xiao-wen; Mu, Yu-rong; Meng, Bo; Liu, Fang-yuan; Li, Rong*. Lentivirus-Mediated Overexpression or Silencing of Aquaporin 1 Affects the Proliferation, Migration and Invasion of TNF-alpha-Stimulated Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Wnt/beta-Catenin Signaling Pathway.Journal of Inflammation Research,2021, 14: 1945-1957.

10. Zhang, Zi-hao#; Qiao, Yu#; Yang, Li#; Chen, Zu-wang; Li, Tao; Gu, Ming-zhen; Li, Chong; Liu, Ming-ming*; Li, Rong*. Kaempferol 3-O-gentiobioside, an ALK5 inhibitor, affects the proliferation, migration, and invasion of tumor cells via blockade of the TGF-beta/ALK5/Smad signaling pathway.Phytotherapy Research,2021, 35(11): 6310-6323.